Vol. 40 No. 3 (2024)

Chronicle and Information

• Welcome by the BioGENext Organizing Committee

  (Author)

  171-172

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• PROGRAM of BioGENext Conference

  (Author)

  173-174

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• Interaction of 5’-monoribonucleotides with Interferon α-2b

  R. O. Nikolaiev, Z. Yu. Tkachuk (Author)

  175-175

  • PDF English

• Spectral analysis of acid and salt forms of nucleotides, their components and complexes with D-mannitol at room temperature

  M. A. Dotsenko, R. O. Nikolaiev, Z. Yu. Tkachuk (Author)

  176-176

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• Interaction between short oligonucleotides and recombinant signaling proteins and their receptors

  O. O. Nuzhnyi, R. O. Nikolaiev, Z. Yu. Tkachuk (Author)

  177-177

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• Amphiphilic cationic calixarenes in HEK-293 transfection

  R. V. Rodik, M. Yu. Kuznietsova, I. V. Bodenchuk, E. V. Zhuravel, V. I. Kalchenko, S. A. Zozulya (Author)

  178-178

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• Protonated nucleotides as a promising class of APIs

  Z. Yu. Tkachuk (Author)

  179-179

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• Screening and structural engineering of lariat-capping ribozymes for use as an alternative mRNA 5`-capping system

  R. M. Vietrov, N. O. Hrubiian, A. I. Olkhovska, I. O. Starenka, R. I. Sydor, O. M. Hubar (Author)

  180-180

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• Synthesis and purification of site-specifically modified T7 RNA polymerase for bioorthogonal conjugation applications

  D. O. Semeniuk, N. O. Hrubiian, S. O. Novosolov, M. O. Trokoz, S. D. Panashchuk, O. M. Hubar (Author)

  181-181

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• Expression and purification of constitutively active S6K1 using dual Bac-to-Bac protein expression system

  A. V. Bdzhola, O. M. Zhyvolup, V. V. Filonenko, O. M. Malanchuk (Author)

  182-182

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• Effects of insulin-like growth factor 1 on proliferation of different cell lines

  O. A. Kachalova, T. Moiseieva, A. G. Portnychenko (Author)

  183-183

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• Structure and mechanisms of stabilization of cytokines EMAP II and AIMP1/p43 in complexes with ligands for biomedical use

  M. V. Kolomiiets, V. M. Zayets, D. M. Lozhko, L. A. Zaika, O. I. Bolsunova, O. I. Kornelyuk (Author)

  184-184

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• Production of recombinant proteins in plant systems through transient gene expression technology

  Ya. R. Sindarovska, M. V. Kuchuk (Author)

  185-185

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• Engineering of crRNA sequences for MAD7 cleavage efficiency optimization

  N. V. Senchenko, N. O. Hrubiian, N. A. Shenderovska, R. I. Sydor, S. O. Novosolov, I. O. Starenka, I. V. Savinova, O. M. Hubar (Author)

  186-186

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• Valproic acid (VPA) exerts different effects on proliferation and viability of 4T1 parental and 4T1 cells overexpressing adaptor protein Ruk/CIN85 by triggering metabolic reprograming in type specific manner

  O. O. Hudkova, N. V. Latyshko, T. O. Kishko, I. P. Krysiuk, O. V. Khudiakova, T. D. Skaterna, I. R. Horak, L. B. Drobot (Author)

  187-187

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• SIRT1 is a promising biomarker of the functional accessibility of chromatin in the oocyte follicular cells

  V. A. Sribna, T. V. Blashkiv (Author)

  188-188

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• Hepatoprotective and metabiotic correction and its effect on the content of free fatty acid in rats with experimental toxic liver injury

  V. I. Didenko, O. O. Halinskyi, I. A. Klenina, Yu. A. Gaidar, A. M. Halinska (Author)

  189-189

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• Improvement of the verification of liver fibrosis using new minimally invasive markers in patients with metabolic-associated steatotic liver disease

  Yu. M. Stepanov, V. I. Didenko, I. A. Klenina, O. M. Tatarchuk, O. P. Petishko (Author)

  190-190

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• Genetic effects of variation at ADH1B-ADH1C locus on substance use disorders and physical health traits

  V. V. Bashynska, O. Zahorodnia, Yu. Borysovych, Yu. Zaplatnikov, V. Vasilyeva, I. Arefiev, D. Krasnienkov, O. Zabuga, N. Darvishov, D. Osichanskaya, A. Karapetyan, O. Melnychuk, O. Boiko, G. M. Zil'berblat, O. I. Turos, I. O. Prokopenko, M. A. Kaakinen (Author)

  191-191

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• Biomarkers of oxidative stress in experimental model of diabetes under administration of fruit extracts from different cultivars of Cornus mas and hybrid Cornus mas × Cornus officinalis

  A. A. Moroz, I. V. Brodyak, A. Z. Kucharska, N. O. Sybirna (Author)

  192-192

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• Epigenetic, transcriptional and splicing changes in the glioblastoma marker genes CHI3L1 and MGMT during the acquisition of temozolomide resistance

  O. V. Anopriienko, M. K. Shuvalova, P. O. Areshkov, A. R. Shloma, K. I. Solomiana, I. Ya. Skrypkina (Author)

  193-193

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• Electrochemical biosensors based on creatinine deiminase for creatinine detection

  V. M. Arkhypova, V. A. Bakhmat, I. S. Knyr, L. V. Shkotova, Yu. V. Karpenko, O. O. Soldatkin, S. V. Dzyadevych (Author)

  194-194

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• Identification of oncogenic mutations in a pedigree affected by inherited cancers: A case report

  A. M. Bezverkhiy, V. O. Kropelnytskyi, R. V. Gulkovskyi (Author)

  195-195

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• Electrochemical enzyme biosensors for medical application

  S. V. Dzyadevych, V. M. Arkhypova, D. O. Mruga, O. O. Soldatkin (Author)

  196-196

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• Detection of clinically significant gene variants in colon adenocarcinoma samples of ukrainian patients using a cancer hotspot panel

  G. V. Gerashchenko, R. V. Gulkovskyi, N. S. Melnichuk, T. V. Marchyshak, O. S. Mankovska, A. M. Bezverkhiy, V. V. Gordiyuk, L. G. Rosha, A. S. Kotuza, O. A. Kolesnik, Z. Yu. Tkachuk, V. I. Kashuba, M. A. Tukalo (Author)

  197-197

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• Alteration in the ratio of S6K1 isoform expression modifies the response of cancer cells to the influences of the tumor microenvironment

  N. Ya. Hotsuliak, V. R. Kosach, V. V. Filonenko, A. I. Khoruzhenko (Author)

  198-198

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• Association of genetic alterations in the EGFR and ALK genes with PD-L1 expression in non-small cell lung cancer

  Yu. V. Moskalenko, D. S. Kozakov, S. S. Livshun, M. I. Panko, O. M. Sulaieva (Author)

  199-199

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• Allelic variant frequency of the MALAT1 gene by rs619581 polymorphism in patients with transitional cell carcinoma of the bladder

  Ye. A. Stroy, Yu. V. Moskalenko, O. A. Obukhova (Author)

  200-200

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• Ganoderma lucidum extract normalizes the concentration of sialic acids in erythrocytes and blood plasma of rats with experimental metabolic syndrome

  T. S. Petryn, M. R. Nagalievska, N. O. Sybirna (Author)

  201-201

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• Next-generation sequencing is a prerequisite for personalized lung cancer treatment

  O. I. Vynnychenko, R. A. Moskalenko, D. S. Kozakov, S. S. Livshun, O. M. Sulaieva (Author)

  202-202

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• The GIWU–CF study: exploring genetic modifiers in cystic fibrosis

  O. Tyshchenko, Yu. Sharhorodska, L. Bober, M. Tyrkus, A. Shmeliov, T. Okul, O. Vashchuk, N. Matiytsiv, I. Prokopenko, H. Makukh (Author)

  203-203

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• Enhancing the response of a hybridization SPR biosensor using modified gold nanoparticles

  M. S. Sobolevskyi, O. O. Soldatkin, A. M. Lopatynskyi, V. I. Chegel, A. V. Samoylov, S. V. Dzyadevych (Author)

  204-204

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• The adaptor protein Ruk/CIN85 is a novel key regulator of epithelial-mesenchymal plasticity in cancer cells and a potential therapeutic target

  L. B. Drobot (Author)

  205-205

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• Evaluation of performance of the same analysis in different programming languages

  I.–A. Ripan, K. Brzezinska, Ye. Makedon (Author)

  206-206

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• Top 30 enriched biological processes in placenta between first and second trimesters of physiological pregnancy

  R. I. Dzhikirba, M. Yu. Obolenskaya (Author)

  207-207

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• Predicting proteases integrated with membranes of gram-negative bacteria and their putative roles

  N. O. Kozyrovska, O. V. Podolich, I. Ye. Zaets, O. A. Havryliuk, H. B. Melnyk, L. A. Zaika, G. V. Zubova (Author)

  208-208

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• Putative G-quadruplexes in the genome of unconventional retrovirus bovine foamy virus

  O. Yu. Limanskaya, O. K. Balak, S. O. Balak, A. P. Limanskii (Author)

  209-209

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• Top 20 differentially expressed genes across trimesters of normal pregnancy

  V. V. Martynenko, Y. O. Zhalilova, O. K. Lyhenko, M. Yu. Obolenskaya (Author)

  210-210

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• Bioinformatic approaches for study of the thiamine–binding proteins

  O. O. Mezhenska, A. V. Rebriev, Yu. M. Parkhomenko (Author)

  211-211

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• Antibodies targeting the spike protein of SARS-CoV-2 can be modified to increase their affinity for new virus variants

  M. Yu. Peka, V. M. Balatsky (Author)

  212-212

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• Novel causal insights into idiopathic pregnancy loss

  Ye. Sharhorodska, A. Ulrich, L. Chorna, I. Shymanska, D. Zastavna, O. R. Gnateyko, C. Scapoli, H. Makukh, I. Prokopenko (Author)

  213-213

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• In silico modeling and in vitro studies in search for new anticancer agents among anthra[1,2-d][1,2,3]triazine-4,7,12(3H)-triones

  M. V. Stasevych, V. I. Zvarych (Author)

  214-214

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• Discovery of potent anti–tuberculosis agents targeting aminoacyl–tRNA synthetases

  G. P. Volynets, S. A. Starosyla, V. G. Bdzhola, S. M. Yarmoluk, M. A. Tukalo (Author)

  215-215

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• Network analysis identified novel disease module in rheumatoid arthritis

  V. V. Bashynska, P. Fau, A. S. Romanenko, A. O. Kompaniiets, P. V. Havrysh, M. V. Mykhailichenko, D. O. Nishchenko, N. M. Kasianchuk, F. Iordachi, O. O. Petrenko (Author)

  216-216

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• Spatially-distributed viral evolutionary analysis of Influenza A Virus (IAV)

  O. B. Zlenko, M. Yu. Kit, O. Bondarenko, A. Edu. Gincu, A. Lucaci (Author)

  217-217

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• A comprehensive benchmarking study of adaptive immune receptor repertoire sequencing data aligners

  F. Iordachi, A. Adamyan, S. Bostan, U. Krektun, L. Calujac, C. Dumitrescu (Author)

  218-218

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• Realistic assortment of novel metagenomics benchmarks with diverse biological and technological characteristics

  N. K. Sharma, K. Chhugani, V. Munteanu, P. Skums, A. Zelikovsky, S. Mangul (Author)

  219-219

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• Assessing microbial genome representation across various reference databases: A comprehensive evaluation

  G. Boldirev, N. Sharma, V. Munteanu, A. Bhavatharini, D. Koslicki, A. Zelikovsky, S. Mangul (Author)

  220-220

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• Good software development practices improve citations of RNA seq tools

  S. Sharma, K. Chhugani, Dhr. Deshpande, S. Mangul (Author)

  221-221

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• Reinvigorating antitumor immunity in brain tumors with short peptides and siRNA–nanocarriers targeting the tumor microenvironment

  B. Kaminska, A. Ellert–Miklaszewska, K. Poleszak, L. Peng, P. Pilanc (Author)

  222-222

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• Effect of gold and silver nanoparticles on the enterocytes cell death in mice

  A. P. Lytvynenko, O. M. Kaleynikova, T. Yu. Voznesenska (Author)

  223-223

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• Association between metabolic-associated fatty liver disease and Covid-19 severity: A genetic analysis

  M. V. Buchynskyi, O. M. Kamyshnyi (Author)

  224-224

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• Isolation and characterization of extracellular vesicles from different types of mesenchymal stromal/stem cells for future translation research

  I. M. Gordiienko, M. V. Shamshur, N. M. Petryk, A. V. Zlatska (Author)

  225-225

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• Analysis of trends in physiologically based pharmacokinetic modelling in silico in translational studies of monoclonal antibodies

  V. P. Narokha, I. V. Nizhenkovska, O. V. Kuznetsova (Author)

  226-226

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• Prevention of Pseudomonas aeruginosa biofilm formation by pyocins

  O. B. Balko, O. I. Balko, N. M. Zholobak, L. V. Avdeeva (Author)

  227-227

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• Engineering designer-recombinases for therapeutic genome editing

  F. Buchholz (Author)

  228-228

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• Flow injection biosensor system for real time determination of heavy metal ions for water monitoring

  V. A. Bakhmat, Yu. D. Panasiuk, O. O. Soldatkin, S. V. Dzyadevych, V. M. Pyeshkova (Author)

  229-229

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• Optimization and adaptation of amperometric biosensor based on lactate oxidase for measuring lactate concentration in blood serum samples

  K. O. Berketa, A. S. Sverstiuk, A. V. Buzhak, S. V. Dzyadevych, O. O. Soldatkin (Author)

  230-230

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• Food additives – carrageenans – in the context of changes in the functional characteristics of body cells

  O. A. Nakonechna, S. A. Denysenko, S. O. Stetsenko (Author)

  231-231

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• The effect of plant alkaloid Chelidonin with fullerene C₆₀ carbon nanoparticles on the permeability of hERG potassium channels

  L. O. Dmytrovska, V. R. Kosach, S. V. Prylutska (Author)

  232-232

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• Antitumor and antimicrobial activity of exometabolites of Black Sea actinobacteria

  V. O. Ivanytsia, T. V. Gudzenko, O. H. Gorshkova, N. V. Korotaieva, I. V. Strashnova, M. D. Shtenikov, G. V. Lisyutin (Author)

  233-233

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• Adaptor protein CIN85 promotes collagen adhesion and invasion of osteosarcoma cells

  I. R. Horak, L. B. Drobot, L. Knopfova (Author)

  234-234

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• «Smart» hydrogel nanocomposites for biomedical applications

  Yu. M. Samchenko, A. P. Maletsky, L. O. Kernosenko, O. A. Samoylenko, I. I. Ganusevich, S. M. Dybkova (Author)

  235-235

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• Alginate gels and nanocomposites with prolonged release of drugs and plant protection agents

  K. Y. Samchenko, O. V. Goncharuk, L. O. Kernosenko, Yu. M. Samchenko (Author)

  236-236

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• Isolation of bacteriophages as therapeutic agents for combating trauma-related infections in Ukraine

  A. V. Kharina, N. O. Korniienko, V. A. Poniatovsky, O. B. Liutko, O. M. Linenko, I. I. Moisa, I. M. Pozhylov, I. G. Budzanivska, H. O. Snihur, O. M. Andriichuk, O. V. Shevchenko (Author)

  237-237

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• Development, optimization, and comparison of two versions of ALT-sensitive biosensor based on glutamate oxidase and pyruvate oxidase

  D. O. Mruga, Ye. P. Vakhovskyi, S. V. Dzyadevych, O. O. Soldatkin (Author)

  238-238

  • PDF English

• Multiplexed High Content Imaging assay optimization for the analysis of apoptosis/necrosis in breast cancer cells after treatment with Vorinostat analogues

  O. M. Oleksiak, V. V. Ripenko, V. R. Kosach (Author)

  239-239

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• Smart biomaterials based on Laponite®: acute toxicity and influence on the redox state and enzyme activity in the organs of the detoxification system of mice

  I. I. Ganusevich, O. A. Samoylenko, A. V. Verbinenko, Yu. M. Samchenko, L. O. Kernosenko, T. P. Poltoratska, N. O. Pasmurtseva, O. O. Solovieva (Author)

  240-240

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• Investigation of the phenyl dihydrouracil molecules as CRBN ligands for the PROTAC development

  V. O. Stadnichenko, O. V. Yakymchuk, P. O. Borysko, G. M. Tolstanova, O. S. Shyshlyk, O. O. Grygorenko (Author)

  241-241

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• Novel non-nucleoside MGMT inhibitors: potential in combined alkylating chemotherapy

  K. S. Zhuvaka, L. L. Macewicz, O. O. Piven, G. P. Volynets, T. P. Ruban, S. M. Yarmoluk, L. L. Lukash (Author)

  242-242

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• Evaluation of phytochemical, antioxidative and antibacterial activities in Hypericum perforatum L. callus cultures

  V. Petrosiute, R. Stankeviciene, I. Tumosiene, K. Kantminiene, I. Jonuskiene (Author)

  243-243

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• Natural alkaloids noncovalently bound to C₆₀ fullerene are potent anticancer phytotherapeutic agents

  O. O. Matyshevska, I. R. Horak, T. D. Skaterna, I. P. Krysiuk, S. P. Lugovskyi, Yu. I. Prylutskyy, L. B. Drobot (Author)

  244-244

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