Valproic acid (VPA) exerts different effects on proliferation and viability of 4T1 parental and 4T1 cells overexpressing adaptor protein Ruk/CIN85 by triggering metabolic reprograming in type specific manner
DOI:
https://doi.org/10.7124/bc.000AC0Keywords:
carcinogenesis, 4T1 cells, Ruk/CIN85, VPAAbstract
Aim. We previously demonstrated that mouse breast adenocarcinoma 4T1 cells overexpressing adaptor protein Ruk/CIN85 (4T1 RukUp) acquired a malignant phenotype associated with cancer stem cells features compared with parental 4T1 cells (4T1 Mock) [1]. VPA, a broad Class I histone deacetylases inhibitor, is widely used in cancer therapy [2]. The study aimed was to evaluate the effect of VPA on Warburg effect dependent on Ruk/CIN85 expression in 4T1 cells. Conclusions. The results obtained demonstrate that VPA restores the coupling between oxidative phosphorylation and glycolysis in 4T1 RukUp cells indicating a novel mechanism of its anti-cancer effects.References
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