Analysis of trends in physiologically based pharmacokinetic modelling in silico in translational studies of monoclonal antibodies

Authors

  • V. P. Narokha O. O. Bogomoletz National Medical University 13, Tarasa Shevchenko Blvd., Kyiv, Ukraine, 01601 Author
  • I. V. Nizhenkovska O. O. Bogomoletz National Medical University 13, Tarasa Shevchenko Blvd., Kyiv, Ukraine, 01601 Author
  • O. V. Kuznetsova O. O. Bogomoletz National Medical University 13, Tarasa Shevchenko Blvd., Kyiv, Ukraine, 01601 Author

DOI:

https://doi.org/10.7124/bc.000ACE

Keywords:

physiologically based pharmacokinetic (PBPK) modelling, antibody, mABs

Abstract

Aim. The aim of the study was to identify trends and directions of using physiologically based pharmacokinetic modelling (PBPK) in silico in translational studies of mABs. Conclusions. Physiologically based pharmacokinetic modelling is used at T0-T3 stages of translational studies of monoclonal antibodies and their fragments, which can be used to solve complex problems in the discovery and development of pharmacotherapeutic agents of this group.
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Published

2024-09-10

Issue

Vol. 40 No. 3 (2024)

Section

Chronicle and Information