Allelic variant frequency of the MALAT1 gene by rs619581 polymorphism in patients with transitional cell carcinoma of the bladder

Abstract

Aim. MALAT1 is a long non-coding RNA with over 3,500 identified polymorphisms, some of which impact the tumor metastasis and prognosis, but data on rs619581 variants in the bladder transitional cell carcinoma patients are lacking. Therefore, the aim of the study was to analyze the distribution of allele variants of the MALAT1 gene by rs619581 polymorphism in the patients from Sumy region of Ukraine with transitional cell carcinoma of the bladder. Conclusions. The distribution of genotypes and alleles by rs619581 polymorphism of the MALAT1 gene does not significantly differ between the patients with transitional cell carcinoma of the bladder and practically healthy individuals living in the Sumy region of Ukraine. No sex-based difference in the polymorphism distribution was found.