Genetic effects of variation at ADH1B-ADH1C locus on substance use disorders and physical health traits

Authors

  • V. V. Bashynska O.M.Marzeiev Institute of Public Health, NAMS of Ukraine 50, Hetmana Pavla Polubotka Str., Kyiv, Ukraine Author
  • O. Zahorodnia Taras Shevchenko National University of Kyiv 64, Volodymyrska Str., Kyiv, Ukraine, 01601 Author
  • Yu. Borysovych Taras Shevchenko National University of Kyiv 64, Volodymyrska Str., Kyiv, Ukraine, 01601 Author
  • Yu. Zaplatnikov Taras Shevchenko National University of Kyiv 64, Volodymyrska Str., Kyiv, Ukraine, 01601 Author
  • V. Vasilyeva Taras Shevchenko National University of Kyiv 64, Volodymyrska Str., Kyiv, Ukraine, 01601 Author
  • I. Arefiev Taras Shevchenko National University of Kyiv 64, Volodymyrska Str., Kyiv, Ukraine, 01601 Author
  • D. Krasnienkov Chebotarov Institute of Gerontology, NAMS of Ukraine 67, Vyshgorodska Str., Kyiv, Ukraine, 04114 Author
  • O. Zabuga Chebotarov Institute of Gerontology, NAMS of Ukraine 67, Vyshgorodska Str., Kyiv, Ukraine, 04114 Author
  • N. Darvishov Taras Shevchenko National University of Kyiv 64, Volodymyrska Str., Kyiv, Ukraine, 01601 Author
  • D. Osichanskaya MedLux Medical Centre 6/8, Mykilsko-Botanichna Str., Kyiv, Ukraine, 01033 Author
  • A. Karapetyan MedLux Medical Centre 6/8, Mykilsko-Botanichna Str., Kyiv, Ukraine, 01033 Author
  • O. Melnychuk Kyiv City Psychoneurological Hospital Number 3, 7, Pavlova Str., Glevakha, Kyiv region, Ukraine, 08631 Author
  • O. Boiko Kyiv City Psychoneurological Hospital Number 3, 7, Pavlova Str., Glevakha, Kyiv region, Ukraine, 08631 Author
  • G. M. Zil'berblat Kyiv City Psychoneurological Hospital Number 3, 7, Pavlova Str., Glevakha, Kyiv region, Ukraine, 08631 Author
  • O. I. Turos O.M.Marzeiev Institute of Public Health, NAMS of Ukraine 50, Hetmana Pavla Polubotka Str., Kyiv, Ukraine Author
  • I. O. Prokopenko University of Surrey Stag Hill, University Campus, Guildford, United Kingdom, GU2 7XH Author
  • M. A. Kaakinen University of Surrey Stag Hill, University Campus, Guildford, United Kingdom, GU2 7XH; Imperial College London South Kensington Campus, London, United Kingdom, SW7 2AZ Author

DOI:

https://doi.org/10.7124/bc.000AE3

Keywords:

genetic association study, substance use disorders, Ukrainians, multi-phenotype study, <em>ADH1B-ADH1C</em>, pleiotropy

Abstract

Aim. We investigated association of a validated in other populations GWAS-identified AD risk locus ADH1B-ADH1C rs1789891 [2-4] with a range of SUDs in Ukrainians and evaluated its potential effects on other traits in GWAS summary statistics from Biobanks. Conclusions. Variations at ADH1B-ADH1C may have pleiotropic effects on SUDs as well as some physical health traits.
biopolym.cell-2024-40-3-cover.png

Downloads

Published

2024-09-10

Issue

Vol. 40 No. 3 (2024)

Section

Chronicle and Information