Alteration in the ratio of S6K1 isoform expression modifies the response of cancer cells to the influences of the tumor microenvironment

Authors

  • N. Ya. Hotsuliak Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03143 Author
  • V. R. Kosach Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03143; Enamine Ltd. 78, Winston Churchill Str., Kyiv, Ukraine, 02094 Author
  • V. V. Filonenko Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03143 Author
  • A. I. Khoruzhenko Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03143 Author

DOI:

https://doi.org/10.7124/bc.000AF7

Keywords:

S6K1 isoforms, tumor microenvironment, cell locomotion,

Abstract

Aim. This work aimed to clarify the impact of mTOR/S6K1 cell signaling, with an emphasis on S6K1 isoforms, in the response of tumor cells to fibroblast influence in vitro. Conclusions. The data highlight the significance of the ratio of S6K1 isoform expression in cancer cells for their response to microenvironment factors.
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Published

2024-09-10

Issue

Vol. 40 No. 3 (2024)

Section

Chronicle and Information