Network analysis identified novel disease module in rheumatoid arthritis

Authors

  • V. V. Bashynska O.M. Marzeiev Institute for Public Health, NAMS Ukraine 50, Hetman Pavlo Polubotka Str., Kyiv, Ukraine, 02094; NGO Genomics UA 3, Dorogozhitska Str., Kyiv, Ukraine, 04119 Author
  • P. Fau Adam Mickiewicz University 1, Wieniawskiego Str., Poznan, Poland, 61–712 Author
  • A. S. Romanenko Adam Mickiewicz University 1, Wieniawskiego Str., Poznan, Poland, 61–712; NGO Genomics UA 3, Dorogozhitska Str., Kyiv, Ukraine, 04119 Author
  • A. O. Kompaniiets Adam Mickiewicz University 1, Wieniawskiego Str., Poznan, Poland, 61–712; NGO Genomics UA 3, Dorogozhitska Str., Kyiv, Ukraine, 04119 Author
  • P. V. Havrysh Institute of Plant Genetics, Polish Academy of Sciences 34, Strzeszynska Str., Poznan, Poland, 60–479; NGO Genomics UA 3, Dorogozhitska Str., Kyiv, Ukraine, 04119 Author
  • M. V. Mykhailichenko University of Wroclaw 1, Uniwersytecki plac, Wroclaw, Poland, 50–137; NGO Genomics UA 3, Dorogozhitska Str., Kyiv, Ukraine, 04119 Author
  • D. O. Nishchenko Taras Shevchenko National University of Kyiv 64, Volodymyrska Str., Kyiv, Ukraine, 01601; NGO Genomics UA 3, Dorogozhitska Str., Kyiv, Ukraine, 04119 Author
  • N. M. Kasianchuk Adam Mickiewicz University 1, Wieniawskiego Str., Poznan, Poland, 61–712; Kyiv School of Economics 3, Mykoly Shpaka Str., Kyiv, Ukraine, 02000; NGO Genomics UA 3, Dorogozhitska Str., Kyiv, Ukraine, 04119 Author
  • F. Iordachi Stanford University's OHS 415, Broadway, Redwood City, CA, United States, 94063 Author
  • O. O. Petrenko Medical University of Vienna 23, Spitalgasse, Vienna, Austria, 1090; NGO Genomics UA 3, Dorogozhitska Str., Kyiv, Ukraine, 04119; Ukrainian Institute for Systems Biology and Medicine 3, Dorogozhitska Str., Kyiv, Ukraine, 04119 Author

DOI:

https://doi.org/10.7124/bc.000AEE

Keywords:

rheumatoid arthritis, network analysis, multiomics

Abstract

Aim. Rheumatoid arthritis (RA) is an autoimmune disease causing chronic joint inflammation and is a leading cause of disability. Despite existing therapies, unmet needs like refractory disease remain a patients’ burden. This study aims to explore molecular associations with RA to identify new biomarkers or molecular targets. Conclusions. The identified molecular associations suggest novel links in RA, offering potential targets for mechanistic studies to understand their role in the disease pathobiology.

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Published

2024-09-10

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Section

Chronicle and Information