Natural alkaloids noncovalently bound to C60 fullerene are potent anticancer phytotherapeutic agents

Authors

  • O. O. Matyshevska O. V. Palladin Institute of Biochemistry, NAS of Ukraine 9, Leontovycha Str., Kyiv, Ukraine, 01054 Author
  • I. R. Horak O. V. Palladin Institute of Biochemistry, NAS of Ukraine 9, Leontovycha Str., Kyiv, Ukraine, 01054 Author
  • T. D. Skaterna O. V. Palladin Institute of Biochemistry, NAS of Ukraine 9, Leontovycha Str., Kyiv, Ukraine, 01054 Author
  • I. P. Krysiuk O. V. Palladin Institute of Biochemistry, NAS of Ukraine 9, Leontovycha Str., Kyiv, Ukraine, 01054 Author
  • S. P. Lugovskyi D. F. Chebotarev Institute of Gerontology, NAMS of Ukraine 67, Vyshgorodska Str., Kyiv, Ukraine, 04114 Author
  • Yu. I. Prylutskyy Taras Shevchenko National University of Kyiv 64, Volodymyrska Str., Kyiv, Ukraine, 01601 Author
  • L. B. Drobot O. V. Palladin Institute of Biochemistry, NAS of Ukraine 9, Leontovycha Str., Kyiv, Ukraine, 01054 Author

DOI:

https://doi.org/10.7124/bc.000AF2

Keywords:

С<sub>60</sub>, alkaloids, nanocomplexes, lung carcinogenesis, tumor growth, EMT, metastasis

Abstract

Aim. Conventional anticancer drugs have a number of known limitations but the development of new ones takes a long time, requires significant funding, and has a low success rate. Repurposing of pharmacologically active plant alkaloids Berberine (Ber) and Piperlongumine (Pl) and finding nanoplatforms for their delivery to cancer cells seems promising to be addressed. The ability of the C60 fullerene (C60) carbon nanostructure to be functionalized with therapeutic agents makes it a potential drug carrier. The aim of this study was to prove a non-covalent functionalization of C60 with Ber or PL and to check the effectiveness of these nanocomplexes against Lewis lung carcinoma (LLC) both in vitro and in vivo. Conclusions. The proposed nanocomplexes of alkaloids with C60 represent promising drugs for the treatment of metastatic lung cancer.

References

Grebinyk A, Prylutska S, Grebinyk S, Evstigneev M, Krysiuk I, Skaterna T, Horak I, Sun Y, Drobot L, Matyshevska O, Prylutskyy Y, Ritter U, Frohme M. Antitumor efficiency of the natural alkaloid berberine complexed with C60 fullerene in Lewis lung carcinoma in vitro and in vivo. Cancer Nanotechnol. 2021; 12(1):24.

Horak I, Prylutska S, Krysiuk I, Luhovskyi S, Hrabovsky O, Tverdokhleb N, Franskevych D, Rumiantsev D, Senenko A, Evstigneev M, Drobot L, Matyshevska O, Ritter U, Piosik J, Prylutskyy Y. Nanocomplex of Berberine with C60 Fullerene Is a Potent Suppressor of Lewis Lung Carcinoma Cells Invasion In Vitro and Metastatic Activity In Vivo. Materials (Basel). 2021; 14(20):6114.

Horak I, Skaterna T, Lugovskyi S, Krysiuk I, Tykhomyrov A, Prylutska S, Tverdokhleb N, Senenko A, Cherepanov V, Drobot L, Matyshevska O, Ritter U, Prylutskyy Y. Antimetastatic lung cancer therapy using alkaloid Piperlongumine noncovalently bound to C60 fullerene. J Drug Deliv Sci Technol. 2024; 92:105275.

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Published

2024-09-10

Issue

Vol. 40 No. 3 (2024)

Section

Chronicle and Information