Effects of insulin-like growth factor 1 on proliferation of different cell lines

Authors

  • O. A. Kachalova O.O. Bogomoletz Institute of Physiology, National Academy of Sciences 4, Akademika Bohomoltsia Str., Kyiv, Ukraine, 01024; Tallinn University of Technology 5, Ehitajate tee, Tallinn, Estonia, 19086 Author
  • T. Moiseieva Tallinn University of Technology 5, Ehitajate tee, Tallinn, Estonia, 19086 Author
  • A. G. Portnychenko O.O. Bogomoletz Institute of Physiology, National Academy of Sciences 4, Akademika Bohomoltsia Str., Kyiv, Ukraine, 01024; ICAMER, NAS of Ukraine 27, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03143 Author

DOI:

https://doi.org/10.7124/bc.000ABE

Keywords:

cell culture, U2OS, PRE, IGF–1, cell proliferation

Abstract

Aim. Targeting cell proliferation may be an important therapeutic purpose in tumor growth, tissue remodeling or degenerative diseases. Insulin-like growth factor IGF-1 is known as a proliferative agent, but its effect in different cellular models may be contradictory due to crosstalk of multiple cellular regulatory pathways [1, 2], and need to be elucidated. The aim was to characterize the proliferative effects of IGF-1 in cells with high and low proliferative activity. Conclusions. IGF-1 causes different proliferative response in the cells with high and low proliferative capacity with nonlinear dependence on time and dose. The tumor U2OS cell proliferation was most suppressed in suspended cells especially with the IGF-1 overdose. In RPE, IGF-1 may be used in low concentrations to increase proliferative capacities and prevent cellular senescence.

References

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Published

2024-09-10

Issue

Vol. 40 No. 3 (2024)

Section

Chronicle and Information