Biopolym. Cell. 1990; 6(1):3-12.
http://dx.doi.org/10.7124/bc.000243
Можливості використання досягнень генної інженерії ссавців для розробки методів генної терапії
1Вайсман Б. Л., 1Дибан А. П.
  1. Інститут експериментальної медицини АМН СРСР
    Ленінград, СРСР

Abstract

На підставі аналізу власних досліджень і даних літератури в галузі генної інженерії ссавців дається оцінка перспектив використання цього напрямку в інтересах розвитку генної терапії. Розглянуто сучасні методи отримання трансгенних тварин, властиві їм особливості інтеграції в геном та експресії чужорідних генів, а також існуючі негативні ефекти на організм впровадження в геном зародків чужорідної ДНК. Підкреслюються широкі можливості генної інженерії тварин для створення строгих генетичних моделей різних патологічних станів людини, придатних для різноманітних експериментів в області генної терапії.
Повний текст: (PDF, російською)

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