Biopolym. Cell. 1990; 6(1):3-12.
http://dx.doi.org/10.7124/bc.000243
Possibilities of using the advances of mammalian gene engineering for elaboration of gene therapy methods
1Vaisman B. L., 1Dyban A. P.
  1. Institute of Experimental Medicine, Academy of Medical Sciences of the USSR
    Leningrad, USSR

Abstract

Evaluation of the prospects to use gene engineering for development of gene therapy is presented on the basis of the authors' research and data from the literature dealing with gene engineering of mammals. Contemporary methods to obtain transgenic animals are regarded with respect to the peculiarities of integration into their genome and expression of foreign genes as well as to the existing negative effects of foreign DNA introduction into the embryonic genome. Wide possibilities opened by animal gene engineering to elaborate accurate genetic models of different pathological human states which may be used for various experiments In the area of gene therapy are emphasized.
Full text: (PDF, in Russian)

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