Від мезенхімальних стовбурових клітин до їх секретомів як основних компонентів дермальних покриттів для лікування масивних опіків

Папуга, О. Є.; Мацевич, Л. Л.; Лукаш, Л. Л.

doi:10.7124/bc.000A91

Biopolym. Cell. 2023; 39(2):90-109.

http://dx.doi.org/10.7124/bc.000A91

Огляди

Від мезенхімальних стовбурових клітин до їх секретомів як основних компонентів дермальних покриттів для лікування масивних опіків

1Папуга О. Є., 1Мацевич Л. Л., 1Лукаш Л. Л.

Інститут молекулярної біології і генетики НАН України
Вул. Академіка Заболотного, 150, Київ, Україна, 03143

Abstract

У результаті проведення багаторічних досліджень нами створено нові біотехнологічні продукти, а саме – дермальні покриття (еквіваленти дерми) з включенням МСК людини або їхніх секретомів (кондиційованих клітинами культуральних середовищ, які містять комплекс синтезованих ними біологічно активних речовин). Проведено доклінічні дослідження нових еквівалентів дерми на модельних тваринах і клінічні випробування на обмеженому контингенті пацієнтів з масивними опіками з метою визначити їхню терапевтичну ефективність, а також безпечність. Ми довели в спеціальних експериментах in vivo, що нові дермальні еквіваленти позитивно впливають на загоєння масивних глибоких опікових ран при аплікації їх на ранову поверхню і не виявляють токсичних властивостей в досліджуваних організмах. Спосіб отримання нових біотехнологічних продуктів запатентовано.

Keywords: клітинна біотехнологія, дермальне покриття або еквівалент дерми, мезенхімальна стовбурова клітина (МСК), кондиційоване середовище (КС), секретом, опіки

Повний текст: (PDF, англійською)

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