From mesenchymal stem cells to their secretoms as basic components of dermal coverings for the treatment of massive burns

Papuga, O. Ye.; Macewicz, L. L.; Lukash, L. L.

doi:10.7124/bc.000A91

Biopolym. Cell. 2023; 39(2):90-109.

http://dx.doi.org/10.7124/bc.000A91

Reviews

From mesenchymal stem cells to their secretoms as basic components of dermal coverings for the treatment of massive burns

1Papuga O. Ye., 1Macewicz L. L., 1Lukash L. L.

Institute of Molecular Biology and Genetics, NAS of Ukraine
150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03143

Abstract

In the course of our long term research, we have created new biotechnological products – dermal coverings (dermis equivalents) with the inclusion of human MSCs or their secretomes (cells conditioned mediums which contain a complex of biologically active substances synthesized by them). Preclinical studies on the model animals and clinical trials of new dermal equivalents on the limited contingent of patients with massive burns have been conducted to determine their therapeutic effectiveness as well as safety. We proved at special in vivo experiments that new dermal coverings contribute positively to the healing severe deep burn wounds when applied to the wound surface and don not reveal any toxic property in the studied organisms. The method of obtaining new biotechnological products has been patented.

Keywords: cellular biotechnology, dermal covering or dermis equivalent, mesenchymal stem cell (MSC), conditioned media (CM), secretome, burns

Full text: (PDF, in English)

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