Biopolym. Cell. 2016; 32(5):334-346.
http://dx.doi.org/10.7124/bc.000930
Огляди
Структурно-функціональне значення мікросателітних повторів ДНК
1Сьяксте Т., 1Парамонова Н., 2Сьяксте Н.
  1. Геноміки та біоінформатики, Інститут біології
    Латвійський університет
    вул. Мієр 3, Саласпилс, Латвія, LV-2169
  2. Медичний факультет,
    Латвійського університету
    бульвар Раїна 19, Рига, Латвія, LV-1586

Abstract

Огляд узагальнює дані літератури про вплив мікросателітних повторів на структуру ДНК і хроматину та результати досліджень щодо зв'язку між довжиною мікросателітних повторів і схильныстю до патологій. У мікросателітних сайтах змінюється вторинна структура ДНК, загальна структура і організація петлі хроматину; повтори сприяють утворенню Z-ДНК, шпильок, триплексів і квадруплексов. Дані досліджень по асоціаціям класифікують по локалізації мікросателітів: у промоторі гена, в області першого екзона, що кодує сигнальну послідовність, в інтронній т частини, та в кодуючий в 3'-UTR ділянках гена.
Keywords: микросателітні повтори ДНК, хроматин, хвороби людини, промотор, інтрон, екзон
Повний текст: (PDF, англійською)

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