Biopolym. Cell. 2014; 30(2):90-95.
http://dx.doi.org/10.7124/bc.000886
Огляди
Транслокації, обумовлені локусом важкого ланцюга гена імуноглобуліну людини
1, 2, 3Скляр І. В., 2, 3Ярова О. В., 1, 3Ліпінський М., 2, 3Васецький Є. С.
  1. Інститут Густава Русі
    вул. Едуарда Вальян, 114, Вільжюіф, Франція, 94805
  2. Інститут біології гена РАН
    вул. Вавілова 34/5, Москва, Російська Федерація, 119334
  3. LIA 1066 Об'єднана французько-російська лабораторія з дослідження раку
    Вільжюіф, Франція-Москва, Російська Федерація

Abstract

Транслокації за участі локуса важкого ланцюга гена імуноглобулінів відіграють певну роль в онкогенезі багатьох лімфом і лейкемій, серед яких множинна мієлома, лімфома мантійної зони, лімфома Беркітта та дифузна В-клітинна лімфома. На основі аналізу опублікованих даних ми виділили 11 областей, у яких відбу- ваються транслокації, що призводять до вищезгаданих лімфом і лейкемій. Кожна з таких областей (розміром приблизно 1000 пар нуклеотидів) може брати участь у транслокаціях, які спричиняють один або декілька типів раку. Отримані результати можна використовувати при розробці діагностики транслокацій, які ви- кликають рак крові, а також при ідентифікації потенційних транслокаційних партнерів локуса важкого ланцюга гена імуно- глобулінів на різних стадіях диференціювання В-лімфоцитів.
Keywords: транслокації, важкий ланцюг імуноглобуліну людини, онкогенез, лімфома, лейкемія, диференціювання В-клітин
Повний текст: (PDF, англійською)

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