Biopolym. Cell. 2014; 30(2):90-95.
http://dx.doi.org/10.7124/bc.000886
Reviews
Translocations affecting human immunoglobulin heavy chain locus
1, 2, 3Sklyar I. V., 2, 3Iarovaia O. V., 1, 3Lipinski M., 2, 3Vassetzky Y. S.
  1. CNRS UMR 8126, Universit Paris-Sud 11, Institut Gustave Roussy
    114, rue Edouard Vaillant, Villejuif, France, 94805
  2. Institute of Gene Biology, Russian Academy of Sciences
    34/5, Vavilova Str., Moscow, Russian Federation, 119334
  3. LIA 1066 French-Russian Joint Cancer Research Laboratory
    Villejuif, France–Moscow, Russian Federation

Abstract

Translocations involving human immunoglobulin heavy chain (IGH) locus are implicated in different leukaemias and lymphomas, including multiple myeloma, mantle cell lymphoma, Burkitt’s lymphoma and diffuse large B cell lymphoma. We have analysed published data and identified eleven breakpoint cluster regions (bcr) related to these cancers within the IgH locus. These ~1 kbp bcrs are specific for one or several types of blood cancer. Our findings could help devise PCR-based assays to detect cancer-related translocations, to identify the mechanisms of translocations and to help in the research of potential translocation partners of the immunoglobulin locus at different stages of B-cell differentiation.
Keywords: translocation, human immunoglobulin heavy chain, oncogenesis, lymphoma, leukaemia, B-cell differentiation.
Full text: (PDF, in English)

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