Biopolym. Cell. 2014; 30(1):16-24.
http://dx.doi.org/10.7124/bc.000878
Огляди
Започаткування системної біології в Україні
1Оболенська М. Ю., 1Токовенко Б. Т., 1Куклін А. В., 1Фролова А. О., 1Родрігес Р. Р., 1Доценко В. А., 1Драгущенко О. О.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

Представлено наукові здобутки першої в Україні (ІМБіГ НАН України) лабораторії системної біології. Вони включають створення веб-інструменту для всегеномного пошуку сайтів зв’язування транскрипційних факторів у промоторах евкаріотних генів; розкриття тонко збалансованого механізму відповіді первинних гепатоцитів на дію інтерферону альфа в дозі, зареєстрованій на першому етапі регенерації печінки після часткової гепатектомії; розробку нового методу інференції мережі генної регуляції для його використання в середовищі ГРІД і створення стехіометричної моделі фолатного циклу у плаценті людини для характеристики поведінки системи за різних патологічних станів.
Keywords: системна біологія, генні регуляторні мережі, метаболічне моделювання, мікроарей
Повний текст: (PDF, англійською)

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