Biopolym. Cell. 2007; 23(3):202-214.
http://dx.doi.org/10.7124/bc.000766
Оксидативні пошкодження ДНК
1Скрипник Н. В., 1Маслова О. О.
  1. Київський національний університет імені Тараса Шевченка
    вул. Володимирська 64, Київ, Україна, 01033

Abstract

Проаналізовано деякі характеристики основних типів оксидативних пошкоджень ДНК: модифікації азотистих основ та дезоксирибози, одноланцюгові та дволанцюгові розриви, апуринові/апіримідинові сайти, міжвалентні взаємодії ДНК з білками. Наведено хімічну структуру найдослідженіших форм оксидативних пошкоджень ДНК. Зазначено найпоширеніші генотоксичні агенти (активні форми кисню, вільні радикали, алкілуючі чинники). Розглянуто сучасні методи якісних і кількісних досліджень пошкоджень ДНК.
Keywords: оксидативний стрес, пошкодження ДНК, генотоксичні агенти
Повний текст: (PDF, українською) (PDF, англійською)

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