Biopolym. Cell. 2007; 23(3):202-214.
Оксидативні пошкодження ДНК
1Скрипник Н. В., 1Маслова О. О.
- Київський національний університет імені Тараса Шевченка
вул. Володимирська 64, Київ, Україна, 01033
Abstract
Проаналізовано деякі характеристики основних типів оксидативних пошкоджень ДНК: модифікації азотистих основ та дезоксирибози, одноланцюгові та дволанцюгові розриви, апуринові/апіримідинові сайти, міжвалентні взаємодії ДНК з білками. Наведено хімічну структуру найдослідженіших форм оксидативних пошкоджень ДНК. Зазначено найпоширеніші генотоксичні агенти (активні форми кисню, вільні радикали, алкілуючі чинники). Розглянуто сучасні методи якісних і кількісних досліджень пошкоджень ДНК.
Keywords: оксидативний стрес, пошкодження ДНК, генотоксичні агенти
Повний текст: (PDF, українською) (PDF, англійською)
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