Biopolym. Cell. 2005; 21(1):12-27.
http://dx.doi.org/10.7124/bc.0006D7
Огляди
Протеїн S-100: структурно-функціональні властивості і роль у нервовій тканині
1Никандров В. М., 1Чаплинська Є. В.
  1. Інститут фізіології HAH Білорусі
    вул. Академічна, 28, Мінськ, Білорусь, 220072

Abstract

Проаналізовано дані літератури стосовно класифікації, ме­тодів виділення, фізико-хімічних властивостей, локалізації у нейронних структурах, динаміки в онтогенезі, механізмів дії і функціональної ролі у нервовій системі, нейротрофічних особливостей, причетності до патогенезу низки захворювань Са2+-зв'язувальних білків групи S-100. Обговорено участь S-100 у клітинних та загальних міжсистемних механізмах життєзабезпечення і пристосувальної активності організму тварин і людини.
Keywords: S-100, нервова система, структура, функції, Са2+
Повний текст: (PDF, російською)

References

[1] Moore BW, Mcgregor D. Chromatographic and electrophoretic fractionation of soluble proteins of brain and liver. J Biol Chem. 1965;240:1647-53.
[2] Moore BW. Brain specific proteins. Proteins of the nervous system. Ed. D. J. Schreider. New York: Raven Press, 1973: 1-12.
[3] Nazaryan KB. Specific proteins of nervous tissue. Zh Nevropatol Psikhiatr im. S. S. Korsa­kova. 1978; 78(2):283-91.
[4] Moore BW, Perez VJ, Gehring M. Assay and regional distribution of a soluble protein characteristic of the nervous system. J Neurochem. 1968;15(4):265-72.
[5] Shtark MB. Brain-specific proteins (antigens) and neuron function. M.: Meditsina, 1985. 319 p.
[6] Donato R. S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol. 2001;33(7):637-68.
[7] Donato R. Intracellular and extracellular roles of S100 proteins. Microsc Res Tech. 2003;60(6):540-51.
[8] Tei I, Koh E, Yokoyama S. [Clinical study of serum S-100 beta protein as marker of brain injury in cardiovascular surgery]. Kyobu Geka. 1999;52(13):1090-4.
[9] Stigbrand T, Nyberg L, Ull?n A, Haglid K, Sandstr?m E, Brundell J. A new specific method for measuring S-100B in serum. Int J Biol Markers. 2000;15(1):33-40.
[10] Kligman D, Hilt DC. The S100 protein family. Trends Biochem Sci. 1988;13(11):437-43.
[11] Beaudeux J, Dequen L, Foglietti M. [Pathophysiologic aspects of S-100beta protein: a new biological marker of brain pathology]. Ann Biol Clin (Paris). 1999;57(3):261-72.
[12] Tiulenev VI, Kapralov AA, Belik IaV. [Role of S-100 protein in the function of brain cell nuclei]. Ukr Biokhim Zh. 1996;68(3):3-13.
[13] Barger SW, Van Eldik LJ. S100 beta stimulates calcium fluxes in glial and neuronal cells. J Biol Chem. 1992;267(14):9689-94.
[14] Poletaev AB, Kupriianenko TI. [Heterogeneity of brain-specific proteins of S100 type]. Biokhimiia. 1980;45(12):2153-7.
[15] Volz A, Korge BP, Compton JG, Ziegler A, Steinert PM, Mischke D. Physical mapping of a functional cluster of epidermal differentiation genes on chromosome 1q21. Genomics. 1993;18(1):92-9.
[16] Ridinger K, Ilg EC, Niggli FK, Heizmann CW, Sch?fer BW. Clustered organization of S100 genes in human and mouse. Biochim Biophys Acta. 1998;1448(2):254-63.
[17] Isobe T, Ishioka N, Okuyama T. Structural relation of two S-100 proteins in bovine brain; subunit composition of S-100a protein. Eur J Biochem. 1981;115(3):469-74.
[18] Berezin VA, Velik YaV. Specific proteins of nervous tissue. Kiev: Naukova Dumka, 1990. 264 c.
[19] Marks A, Allore R. S100 protein and Down syndrome. Bioessays. 1990;12(8):381-3.
[20] Petzold A, Jenkins R, Watt HC, Green AJ, Thompson EJ, Keir G, Fox NC, Rossor MN. Cerebrospinal fluid S100B correlates with brain atrophy in Alzheimer's disease. Neurosci Lett. 2003;336(3):167-70.
[21] Watson PH, Leygue ER, Murphy LC. Psoriasin (S100A7). Int J Biochem Cell Biol. 1998;30(5):567-71.
[22] Emberley ED, Niu Y, Njue C, Kliewer EV, Murphy LC, Watson PH. Psoriasin (S100A7) expression is associated with poor outcome in estrogen receptor-negative invasive breast cancer. Clin Cancer Res. 2003;9(7):2627-31.
[23] Renaud W, Merten M, Figarella C. Increased coexpression of CFTR and S100 calcium binding proteins MRP8 and MRP14 mRNAs in cystic fibrosis human tracheal gland cells. Biochem Biophys Res Commun. 1994;201(3):1518-25.
[24] Kerkhoff C, Klempt M, Sorg C. Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9). Biochim Biophys Acta. 1998;1448(2):200-11.
[25] Tan M, Heizmann CW, Guan K, Schafer BW, Sun Y. Transcriptional activation of the human S100A2 promoter by wild-type p53. FEBS Lett. 1999;445(2-3):265-8.
[26] Stradal TB, Gimona M. Ca(2+)-dependent association of S100A6 (Calcyclin) with the plasma membrane and the nuclear envelope. J Biol Chem. 1999;274(44):31593-6.
[27] Fleminger G, Neufeld T, Star-Weinstock M, Litvak M, Solomon B. Calcium-modulated conformational affinity chromatography. Application to the purification of calmodulin and S100 proteins. J Chromatogr. 1992;597(1-2):263-70.
[28] Johnston PA, S?dhof TC. Evolutionary conservation and structural determinants of the calelectrins (annexins). Biochem Soc Trans. 1990;18(6):1097-8.
[29] Becker T, Gerke V, Kube E, Weber K. S100P, a novel Ca(2+)-binding protein from human placenta. cDNA cloning, recombinant protein expression and Ca2+ binding properties. Eur J Biochem. 1992;207(2):541-7.
[30] Bianchi R, Pula G, Ceccarelli P, Giambanco I, Donato R. S-100 protein binds to annexin II and p11, the heavy and light chains of calpactin I. Biochim Biophys Acta. 1992;1160(1):67-75.
[31] Starostina MB, Sviridov SM. Neurospecific protein S-100. Usp Sovrem Biol. 1977; 84, (2 (5)): 176-88.
[32] Mahadik SP, Graf L, Korenovsky A, Rapport MM. Immunochemical properties of S-100 proteins and their subunits. J Neurochem. 1979;33(3):763-71.
[33] Abe T, Takahashi K, Ando T. Purification and properties of S-100 protein from porcine brain. J Biochem. 1974;75(1):11-22.
[34] Maletskaia EI, Bakhtina TK, Vysotskiĭ MV, Sviridov SM. [The heterogeneity of neurospecific S-100 protein]. Biokhimiia. 1976;41(1):40-9.
[35] Haglid KG, Stavrou D, R?nnb?ck L, Carlsson CA, Weidenbach W. The S-100 protein in water-soluble and pentanol-extractable form in normal human brain and tumours of the human nervous system. A quantitative study. J Neurol Sci. 1973;20(1):103-11.
[36] Beliaev SV, Kupriianenko TI, Lysova NP, Poletaev AB. [Physico-chemical, antigenic and enzymatic properties of protein S100]. Biokhimiia. 1981;46(12):2193-201.
[37] Sergeichik NL, Zhavoronok SV, Tarasyuk IV. Isolation nero specific protein group S-100B and the creation of enzyme immunoassay test kit for the detection of antibodies to it. Vestci NAN Belarus Ser. Med. Biol. Nauk. 2003;4: 109-113.
[38] Mancini G, Carbonara AO, Heremans JF. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965;2(3):235-54.
[39] Viazovaia EA, Malup TK, Sviridov SM. [Content of neurospecific protein S-100 in the brain of mice of different inbred lines]. Dokl Akad Nauk SSSR. 1975;225(5):1194-7.
[40] Malup TK, Sviridov SM. [Dynamics of neurospecific protein S-100 accumulation in the brain of AKR/J and DBA/2J strain mice in the process of postnatal development]. Ontogenez. 1978;9(2):189-93.
[41] Miles LE, Lee YL, Eng LF. Calcium ion dependence of the 2-site immunoradiometric assay of Moore's S-100 protein. J Neurochem. 1977;28(6):1201-5.
[42] Aurell A, Rosengren LE, Wikkels? C, Nordberg G, Haglid KG. The S-100 protein in cerebrospinal fluid: a simple ELISA method. J Neurol Sci. 1989;89(2-3):157-64.
[43] Starostina MV, Sviridov SM. [Quantitative determination of neurospecific protein S-100 in mouse brain cortical synaptosomes]. Biokhimiia. 1981;46(11):2030-42.
[44] Dannies PS, Levine L. Structural properties of bovine brain S-100 protein. J Biol Chem. 1971;246(20):6276-83.
[45] Stewart JA. Tissue specific brain S-100. A demonstration of multiple proteins. Biochim Biophys Acta. 1972;263(1):178-92.
[46] Isobe T, Tsugita A, Okuyama T. The amino acid sequence and the subunit structure of bovine brain S-100 protein (PAP I-b). J Neurochem. 1978;30(4):921-3.
[47] Kessler D, Levine L, Fasman G. Some conformational and immunological properties of a bovine brain acidic protein (S-100). Biochemistry. 1968;7(2):758-64.
[48] Garbuglia M, Verzini M, Sorci G, Bianchi R, Giambanco I, Agneletti AL, Donato R. The calcium-modulated proteins, S100A1 and S100B, as potential regulators of the dynamics of type III intermediate filaments. Braz J Med Biol Res. 1999;32(10):1177-85.
[49] Matsuda S. Dimer of S-100 Proteins. Bull Chem Soc Jpn. 1994;67(3):888–90.
[50] Kato K, Haimoto H, Ariyoshi Y, Horisawa M, Washida H, Kimura S. High levels of S-100a0 (alpha alpha) protein in tumor tissues and in sera of patients with renal cell carcinoma. Jpn J Cancer Res. 1985;76(9):856-62.
[51] Heizmann CW, Cox JA. New perspectives on S100 proteins: a multi-functional Ca(2+)-, Zn(2+)- and Cu(2+)-binding protein family. Biometals. 1998;11(4):383-97.
[52] Calissano P, Moore BW, Friesen A. Effect of calcium ion on S-100, a protein of the nervous system. Biochemistry. 1969;8(11):4318-26.
[53] Pingerelli PL, Mizukami H, Wagner AS, Bartnicki DE, Oliver JP. Investigation of the Ca2(+)-dependent interaction of trifluoperazine with S100a: a 19F NMR and circular dichroism study. J Protein Chem. 1990;9(2):169-75.
[54] Mely Y, G?rard D. Intra- and interchain disulfide bond generation in S100b protein. J Neurochem. 1990;55(4):1100-6.
[55] Deloulme JC, Assard N, Mbele GO, Mangin C, Kuwano R, Baudier J. S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo. J Biol Chem. 2000;275(45):35302-10.
[56] Baudier J, Glasser N, Gerard D. Ions binding to S100 proteins. I. Calcium- and zinc-binding properties of bovine brain S100 alpha alpha, S100a (alpha beta), and S100b (beta beta) protein: Zn2+ regulates Ca2+ binding on S100b protein. J Biol Chem. 1986;261(18):8192-203.
[57] Nishikawa T, Lee IS, Shiraishi N, Ishikawa T, Ohta Y, Nishikimi M. Identification of S100b protein as copper-binding protein and its suppression of copper-induced cell damage. J Biol Chem. 1997;272(37):23037-41.
[58] Sch?fer BW, Fritschy JM, Murmann P, Troxler H, Durussel I, Heizmann CW, Cox JA. Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily. J Biol Chem. 2000;275(39):30623-30.
[59] Suzuki F, Nakajima T, Kato K. Peripheral distribution of nervous system-specific S-100 protein in rat. J Biochem. 1982;92(3):835-8.
[60] Hyd?n H, McEwen B. A glial protein specific for the nervous system. Proc Natl Acad Sci U S A. 1966;55(2):354-8.
[61] Stewart JA, Urban MI. The postnatal accumulation of S-100 protein in mouse central nervous system. Modulation of protein synthesis and degradation. Dev Biol. 1972;29(4):372-84.
[62] Zimmer DB, Van Eldik LJ. Tissue distribution of rat S100 alpha and S100 beta and S100-binding proteins. Am J Physiol. 1987;252(3 Pt 1):C285-9.
[63] Gaynor R, Irie R, Morton D, Herschman HR. S100 protein is present in cultured human malignant melanomas. Nature. 1980;286(5771):400-1.
[64] Cocchia D. Immunocytochemical localization of S-100 protein in the brain of adult rat. An ultrastructural study. Cell Tissue Res. 1981;214(3):529-40.
[65] Korochkin LI, Sviridov SM, Ivanov VN, Maletskaia EN, Bakhtina TK. [Immunohistochemical identification of S-100 protein in the brain of rats of 2 lines in postnatal ontogenesis]. Dokl Akad Nauk SSSR. 1972;204(2):468-70.
[66] Michetti F, Miani N, De Renzis G, Caniglia A, Correr S. Nuclear localization of S-100 protein. J Neurochem. 1974;22(2):239-44.
[67] Kapralov AA, Smertchinskaya LS, Velik YaV, Tyulenev VI. [Intranuclear distribution neurospecific S-100 protein in the cerebellum bull]. Neirokhimia. 1983; 2(1):26—33.
[68] Kapralov AA, Tyulenev VI, Velik YaV. [The presence neurospecific protein S-100 in the Lamin-pore complex nuclei of brain cells and its effect on the phosphorylation of proteins of the nuclear membrane]. Neirokhimia. 1986; 5(4):365-70.
[69] Donato R. The specific interaction of S-100 protein with synaptosomal particulate fractions. Evidence for the formation of a tight complex between S-100 and its binding sites. J Neurochem. 1981;36(2):532-7.
[70] Rusca G, Calissano P, Alema S. Identification of a membrane bound fraction of the S-100 protein. Brain Res. 1973;49(1):223-7.
[71] Hyd?n H, Lange PW. The effect of S100 protein on the plasma membrane function of neurons. Cell Mol Neurobiol. 1981;1(3):313-7.
[72] Donato R. Further studies on the specific interaction of S-100 protein with synaptosomal particulates. J Neurochem. 1976;27(2):439-47.
[73] Herschman HR, Levine L, De Vellis J. Appearance of a brain-specific antigen (S-100 protein) in the developing rat brain. J Neurochem. 1971;18(4):629-33.
[74] Haglid KG, Hansson HA, R?nnb?ck L. S-100 in the central nervous system of rat, rabbit and guinea pig during postnatal development. Brain Res. 1977;123(2):331-45.
[75] Zuckerman JE, Herschman HR, Levine L. Appearance of a brain specific antigen (th S-100 protein) during human foetal development. J Neurochem. 1970;17(2):247-51.
[76] Shtartak RB. Immuno neurophysiology. L.: Meditsina, 1978; 175 p.
[77] Aleksidze NG, Berezhnoy GA, Nikuradze VO, Velik YaV. On the question of the specificity of protein S-100 in the processes of learning and memory. Neirokhimia. 1982; 1(1):43-50.
[78] Nikitin VP, Lazetic B, Baic M, Sherstnev VV. [Participation of brain-specific S-100-group proteins in the neurophysiological mechanisms of habituation]. Neirofiziologiia. 1987;19(5):637-45.
[79] Sherstnev VV, Kochetkov NV, Belyaev SV, Lysova NP, Dolgov ON, Poletaev AB. the effect of endogenous ligands oligopeptide neurospecific proteins S-100 group on the behavior. Neirokhimia. 1983; 2(3):319-22.
[80] Gromov LA, Syrovatskaya LP, Ovinova GV. The functional role of neurospecific protein S-100 in memory processes. Zh Vysch Nervn Deyateln. 1991; 41(1):60-65.
[81] Smerchinskaya LS, Lakomova EYu, Belik TaV. The content of neurospecific protein S-100 in certainareas of hamster brain in the state of hibernation and after artifical awakening. Doklady Akad Nauk Ukr SSR. Ser B. 1982; (3):71-3.
[82] Winocur G, Roder J, Lobaugh N. Learning and memory in S100-beta transgenic mice: an analysis of impaired and preserved function. Neurobiol Learn Mem. 2001;75(2):230-43.
[83] Park ES, Park CI, Baek SY, Kim SW, Baek SK, Kim HO. Serum immunoreactivity to S-100 in children with cerebral palsy and delayed development and in their healthy parents. Yonsei Med J. 2000;41(3):328-32.
[84] Saidakhmetova AS, Rylov AL, Dolgov ON, Sherstenev VV. Predatory aggression rats after intraventricular brain-specific proteins vvedeniyaotdelnyh group S-100 and their peptide fragments. Zh Vysch Nervn Deyateln. 1986; 36(3):502-6.
[85] Rylov AL, Sherstenev VV. Effect of endogenous oligopeptides and brain specific proteins on the aggressive behavior of rats. Zh Vysch Nervn Deyateln. 1984; 34(5):904-10.
[86] Saydakhmetova AS, Sherstenev VV. Participation of the brain-specific protein group are S-100 in the formation of various types of innate behavior of animals. Proc. 27 Meet. HNA. L.: Nauka, 1984:186.
[87] Maslova IV, SHavchenko NV, Babynina DN, Khomenko AI, Sherstenev VV, Poletaev AB, Dolgov OP. Effect of S-100 protein on the metabolism of neurotransmitters in the brain of rats and some aspects of their behavior. 9th AllUnion. Conf. on the biochemistry of the nervous system. Proc. Yerevan: Izd AN ARMSSR, 1983;296.
[88] Gallo V, Levi G, Raiteri M, Coletti A. A nervous system specific protein potentiates the biological effects of the calcium ionophore A23187. Life Sci. 1980;27(9):761-9.
[89] Hyd?n H, Lange PW, Larsson S. S100-glia regulation of GABA transport across the nerve cell membrane. J Neurol Sci. 1980;45(2-3):303-16.
[90] Labourdette G, Mandel P. Effect of norepinephrine and dibutyryl cyclic AMP on S-100 protein level in C6 glioma cells. Biochem Biophys Res Commun. 1980;96(4):1702-9.
[91] Mahadik SP, Graf L, Rapport MM. Immunochemical studies of the interaction between myelin basic protein and S-100 protein. J Neurochem. 1976;27(2):405-8.
[92] Poletaev AB, Meshcheriakova OD. [New data on the function of brain-specific proteins S100: interactions with tubulin from nerve tissue]. Biokhimiia. 1982;47(11):1835-8.
[93] Azmitia EC. Cajal's hypotheses on neurobiones and neurotropic factor match properties of microtubules and S-100 beta. Prog Brain Res. 2002;136:87-100.
[94] Engidawork E, Lubec G. Protein expression in Down syndrome brain. Amino Acids. 2001;21(4):331-61.
[95] Hertz L, Hansson E, R?nnb?ck L. Signaling and gene expression in the neuron-glia unit during brain function and dysfunction: Holger Hyd?n in memoriam. Neurochem Int. 2001;39(3):227-52.
[96] Griffin WS, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ, White CL 3rd, Araoz C. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci U S A. 1989;86(19):7611-5.
[97] Kapralov AA, Tyulenev VI, NAzarenko VI. Effect of protein S-100 transport of RNA in the cell nuclei of rat brain and ATPase activity of the nuclear membrane. Neirokhimia. 1986; 5(2): 219-220.
[98] Kapralov AA, Tyulenev VI. Effect of neurospecific S-100 protein on the RNA release from isolated nuclei of rat brain and liver. Doklady Akad Nauk Ukr SSR. Ser B. 1985; (4):65-67.
[99] Agutter PS, McCaldin B, McArdle HJ. Importance of mammalian nuclear-envelope nucleoside triphosphatase in nucleo-cytoplasmic transport of ribonucleoproteins. Biochem J. 1979;182(3):811-9.
[100] Tiulenev VI, Kapralov AA, Smerchinskaia LS, Belik IaV. [Effect of protein S-100 on phosphorylation of nuclear proteins of cells of rat brain and liver]. Biokhimiia. 1983;48(5):827-32.
[101] Kapralov AA, Balkov DI, Tiulenev VI, Velik YaV. Effect of S-100 protein phosphorylation nuclear proteins of rat brain; involvement of Ca2 +. Neirokhimia. 1985; 4(1):23-9.
[102] Krueger BK, Forn J, Greengard P. Depolarization-induced phosphorylation of specific proteins, mediated by calcium ion influx, in rat brain synaptosomes. J Biol Chem. 1977;252(8):2764-73.
[103] Patel J, Marangos PJ. Modulation of brain protein phosphorylation by the S-100 protein. Biochem Biophys Res Commun. 1982;109(4):1089-93.
[104] Gonzalez-Martinez T, Perez-Pi?era P, D?az-Esnal B, Vega JA. S-100 proteins in the human peripheral nervous system. Microsc Res Tech. 2003;60(6):633-8.
[105] Dedkov EI, Kostrominova TY, Borisov AB, Carlson BM. Survival of Schwann cells in chronically denervated skeletal muscles. Acta Neuropathol. 2002;103(6):565-74.
[106] Atsumi Y, Matsumoto K, Sakuda M, Maeda T, Kurisu K, Wakisaka S. Altered distribution of Schwann cells in the periodontal ligament of the rat incisor following resection of the inferior alveolar nerve: an immunohistochemical study on S-100 proteins. Brain Res. 1999;849(1-2):187-95.
[107] Donato R. Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type. Biochim Biophys Acta. 1999;1450(3):191-231.
[108] Missotten GS, Tang NE, Korse CM, Hurks HM, de Wolff-Rouendaal D, Keunen JE, Jager MJ, Bonfrer JM. Prognostic value of S-100-beta serum concentration in patients with uveal melanoma. Arch Ophthalmol. 2003;121(8):1117-9.
[109] Gentil BJ, Delphin C, Mbele GO, Deloulme JC, Ferro M, Garin J, Baudier J. The giant protein AHNAK is a specific target for the calcium- and zinc-binding S100B protein: potential implications for Ca2+ homeostasis regulation by S100B. J Biol Chem. 2001;276(26):23253-61.
[110] Fan? G, Biocca S, Fulle S, Mariggi? MA, Belia S, Calissano P. The S-100: a protein family in search of a function. Prog Neurobiol. 1995;46(1):71-82.
[111] Fan? G, Mariggi? MA, Angelella P, Nicoletti I, Antonica A, Fulle S, Calissano P. The S-100 protein causes an increase of intracellular calcium and death of PC12 cells. Neuroscience. 1993;53(4):919-25.
[112] Whitaker-Azmitia PM, Clarke C, Azmitia EC. Localization of 5-HT1A receptors to astroglial cells in adult rats: implications for neuronal-glial interactions and psychoactive drug mechanism of action. Synapse. 1993;14(3):201-5.
[113] Whitaker-Azmitia PM, Azmitia EC. Astroglial 5-HT1a receptors and S-100 beta in development and plasticity. Perspect Dev Neurobiol. 1994;2(3):233-8.
[114] Tagliaferro P, Ramos AJ, L?pez EM, Pecci Saavedra J, Brusco A. Neural and astroglial effects of a chronic parachlorophenylalanine-induced serotonin synthesis inhibition. Mol Chem Neuropathol. 1997;32(1-3):195-211.
[115] Ahlemeyer B, Beier H, Semkova I, Schaper C, Krieglstein J. S-100beta protects cultured neurons against glutamate- and staurosporine-induced damage and is involved in the antiapoptotic action of the 5 HT(1A)-receptor agonist, Bay x 3702. Brain Res. 2000;858(1):121-8.
[116] Barrack ER. Steroid hormone receptor localization in the nuclear matrix: interaction with acceptor sites. J Steroid Biochem. 1987;27(1-3):115-21.
[117] Verheijen R, van Venrooij W, Ramaekers F. The nuclear matrix: structure and composition. J Cell Sci. 1988;90 ( Pt 1):11-36. Review.
[118] Zbarskiy IB. The organization of the cell nucleus. M.: Meditsina, 1988; 368 p.
[119] Kapralov AA, Tyulenev VI, Velik YaV. On the participation of protein S-100 protein phosphorylation in the nucleoplasm of the brain and its presence in ribonucleoprotein particles. Neirokhimia. 1988; 7(3):382-8.
[120] Michetti F, Donato R. Subnuclear distribution of the S-100 protein specific binding sites in rat brain. J Neurochem. 1981;36(5):1706-11.
[121] Georgiev GP. Genes in higher organisms and their expression. Moscow, Nauka, 1989. 254 p.
[122] Cheung WY. Calmodulin plays a pivotal role in cellular regulation. Science. 1980;207(4426):19-27.
[123] Qi DF, Kuo JF. S-100 modulates Ca2+-independent phosphorylation of an endogenous protein (Mr = 19K) in brain. J Neurochem. 1984;43(1):256-60.
[124] Ashapkin VV, Vanyushin BF. Differential gene activity in the brains of animals and biochemical mechanisms of its regulation. Usp Sovrem Biol. 1984; 98(3(6)):323-37.
[125] Grouse L, Omenn GA, McCarthy BJ. Studies by DNA-RNA hybridization of transcriptional diversity in human brain. J Neurochem. 1973;20(4):1063-73.
[126] Kurimoto M, Hirashima Y, Ogiichi T, Hamada H, Kamiyama H, Endo S. Establishment and characterization of a novel malignant astrocytoma cell line derived from a tumor removed in a patient with neurofibromatosis type 1. J Neurosurg. 2001;94(2):301-8.
[127] Klushnik TP, Gratchev VV, Belichenko PV. Brain-directed autoantibodies levels in the serum of Rett syndrome patients. Brain Dev. 2001;23 Suppl 1:S113-7.
[128] Poletaev AB, Morozov SG, Gnedenko BB, Zlunikin VM, Korzhenevskey DA. Serum anti-S100b, anti-GFAP and anti-NGF autoantibodies of IgG class in healthy persons and patients with mental and neurological disorders. Autoimmunity. 2000;32(1):33-8.
[129] Iwanaga T, Takahashi Y, Fujita T. Immunohistochemistry of neuron-specific and glia-specific proteins. Arch Histol Cytol. 1989;52 Suppl:13-24.
[130] Aurell A, Rosengren LE, Karlsson B, Olsson JE, Zbornikova V, Haglid KG. Determination of S-100 and glial fibrillary acidic protein concentrations in cerebrospinal fluid after brain infarction. Stroke. 1991;22(10):1254-8.
[131] Becker L, Mito T, Takashima S, Onodera K. Growth and development of the brain in Down syndrome. Prog Clin Biol Res. 1991;373:133-52.
[132] Popovi? M, Sketelj J, Bresjanac M. Changes of Schwann cell antigenic profile after peripheral nerve injury. Pflugers Arch. 1996;431(6 Suppl 2):R287-8.
[133] Hu SN, Xu JG, Gu YD. [Immunohistochemical study of S-100 protein in degenerative nerve after different pathological brachial plexus injuries]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 1999;13(4):209-12.
[134] Sch?fer BW, Heizmann CW. The S100 family of EF-hand calcium-binding proteins: functions and pathology. Trends Biochem Sci. 1996;21(4):134-40.
[135] Zhao G, Yang Y, Su X. [Determination of S-100 beta protein in cerebrospinal fluid of patients with metastatic carcinoma to central nervous system]. Zhonghua Nei Ke Za Zhi. 2000;39(11):732-4.
[136] Schmidt O, Fleckenstein GH, Gunawan B, F?zesi L, Emons G. Recurrence and rapid metastasis formation of a granular cell tumor of the vulva. Eur J Obstet Gynecol Reprod Biol. 2003;106(2):219-21.
[137] Cochran AJ, Lu HF, Li PX, Saxton R, Wen DR. S-100 protein remains a practical marker for melanocytic and other tumours. Melanoma Res. 1993;3(5):325-30. Review.
[138] Perry A, Roth KA, Banerjee R, Fuller CE, Gutmann DH. NF1 deletions in S-100 protein-positive and negative cells of sporadic and neurofibromatosis 1 (NF1)-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors. Am J Pathol. 2001;159(1):57-61.
[139] S?der S, Inwards C, M?ller S, Kirchner T, Aigner T. Cell biology and matrix biochemistry of chondromyxoid fibroma. Am J Clin Pathol. 2001;116(2):271-7.
[140] Sánchez-Huerta V, Rodr?guez-Reyes AA, Hern?ndez-Quintela E, Ram?rez M, Rodr?guez-Mart?nez HA, Naranjo-Tackman R. A corneal diffuse neurofibroma as a manifestation of von recklinghausen disease. Cornea. 2003;22(1):59-62.
[141] Messerli SM, Tang Y, Giovannini M, Bronson R, Weissleder R, Breakefield XO. Detection of spontaneous schwannomas by MRI in a transgenic murine model of neurofibromatosis type 2. Neoplasia. 2002;4(6):501-9.
[142] Hachitanda Y, Nakagawara A, Nagoshi M, Tsuneyoshi M. Prognostic value of N-myc oncogene amplification and S-100 protein positivity in children with neuroblastic tumors. Acta Pathol Jpn. 1992;42(9):639-44.
[143] Hu S, Zhang L, Wen S, Li D. [Detection of S-100 protein in laryngeal carcinoma]. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2001;15(3):110-1.
[144] Tulchinsky EM, Ebralidze AK, Grigorian MS, Mil'shina NV, Lukanidin EM. Structural characterization of mts271 - a new gene for calcium-binding protein. Genetika. 1989; 25(7):1150-9.
[145] Kaskel P, Berking C, Sander S, Volkenandt M, Peter RU, Kr?hn G. S-100 protein in peripheral blood: a marker for melanoma metastases: a prospective 2-center study of 570 patients with melanoma. J Am Acad Dermatol. 1999;41(6):962-9.
[146] Ghanem G, Loir B, Morandini R, Sales F, Lienard D, Eggermont A, Lejeune F; EORTC Melanoma Group. On the release and half-life of S100B protein in the peripheral blood of melanoma patients. Int J Cancer. 2001;94(4):586-90.
[147] Portela LV, Brenol JC, Walz R, Bianchin M, Tort AB, Canabarro UP, Beheregaray S, Marasca JA, Xavier RM, Neto EC, Gon?alves CA, Souza DO. Serum S100B levels in patients with lupus erythematosus: preliminary observation. Clin Diagn Lab Immunol. 2002;9(1):164-6.
[148] Bobryshev YV, Lord RS. S-100 positive cells in human arterial intima and in atherosclerotic lesions. Cardiovasc Res. 1995;29(5):689-96.
[149] van Dongen EP, ter Beek HT, Schepens MA, Morshuis WJ, Haas FJ, de Boer A, Boezeman EH, Aarts LP. The relationship between evoked potentials and measurements of S-100 protein in cerebrospinal fluid during and after thoracoabdominal aortic aneurysm surgery. J Vasc Surg. 1999;30(2):293-300.
[150] Koide M, Kunii Y, Moriki N, Ayusawa Y, Sakai A. Clinical significance of serum S-100 beta protein level after pediatric cardiac surgery. Jpn J Thorac Cardiovasc Surg. 2002;50(7):280-3.
[151] Skvortsova VI, Sherstnev VV, Gruden MA, Myasoedov NF, Stakhovskaya LV, Efremova NM, Khadzhieva MKh, Grivennikov IA, Klyushnik TP, Chaschikhina EV, Kuzhylina VB. The role of autoimmune mechanisms in the damaging effect of cerebral ischemia. Zh Nevropatol Psikhiatr im SS Korsakova. 2001; 1:46-54.
[152] Hachimi-Idrissi S, Van der Auwera M, Schiettecatte J, Ebinger G, Michotte Y, Huyghens L. S-100 protein as early predictor of regaining consciousness after out of hospital cardiac arrest. Resuscitation. 2002;53(3):251-7.
[153] Kim JS, Yoon SS, Kim YH, Ryu JS. Serial measurement of interleukin-6, transforming growth factor-beta, and S-100 protein in patients with acute stroke. Stroke. 1996;27(9):1553-7.
[154] Johnsson P, Lundqvist C, Lindgren A, Ferencz I, Alling C, St?hl E. Cerebral complications after cardiac surgery assessed by S-100 and NSE levels in blood. J Cardiothorac Vasc Anesth. 1995;9(6):694-9.
[155] Astudillo R, Van der Linden J, Radegran K, Hansson LO, Aberg B. Elevated serum levels of S-100 after deep hypothermic arrest correlate with duration of circulatory arrest. Eur J Cardiothorac Surg. 1996;10(12):1107-12.
[156] Ros?n H, Rosengren L, Herlitz J, Blomstrand C. Increased serum levels of the S-100 protein are associated with hypoxic brain damage after cardiac arrest. Stroke. 1998;29(2):473-7.
[157] Lefranc F, Golzarian J, Chevalier C, DeWitte O, Pochet R, Heizman C, Decaestecker C, Brotchi J, Salmon I, Kiss R. Expression of members of the calcium-binding S-100 protein family in a rat model of cerebral basilar artery vasospasm. J Neurosurg. 2002;97(2):408-15.
[158] Leutmezer F, Wagner O, Baumgartner C. Serum s-100 protein is not a suitable seizure marker in temporal lobe epilepsy. Epilepsia. 2002;43(10):1172-4.
[159] Machado-Vieira R, Lara DR, Portela LV, Gon?alves CA, Soares JC, Kapczinski F, Souza DO. Elevated serum S100B protein in drug-free bipolar patients during first manic episode: a pilot study. Eur Neuropsychopharmacol. 2002;12(3):269-72.
[160] Anderson RE, Hansson LO, Nilsson O, Dijlai-Merzoug R, Settergren G. High serum S100B levels for trauma patients without head injuries. Neurosurgery. 2001;48(6):1255-8.
[161] Pleines UE, Morganti-Kossmann MC, Rancan M, Joller H, Trentz O, Kossmann T. S-100 beta reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury. J Neurotrauma. 2001;18(5):491-8.
[162] Shimizu S, Yoshinouchi T, Ohtsuki Y, Fujita J, Sugiura Y, Banno S, Yamadori I, Eimoto T, Ueda R. The appearance of S-100 protein-positive dendritic cells and the distribution of lymphocyte subsets in idiopathic nonspecific interstitial pneumonia. Respir Med. 2002;96(10):770-6.