Biopolym. Cell. 2002; 18(3):205-218.
Структура та функції біополімерів
Природа та можливі механізми утворення потенційних мутацій, що виникають за появи тимінових димерів після опромінення дволанцюгової ДНК ультрафіолетовим світлом
1Гребнева О. А.
  1. Донецький фізико-технічний інститут ім. О. О. Галкіна НАН України
    вул. Рози Люксембург, 72, Донецьк, Україна, 83114

Abstract

Пропонуються механізми мутагенезу, викликаного УФ-опроміненням. Припускається, що основними пошкодженнями, що призводять до транзицій, трансверсій, мутацій зсуву рамки зчитування та до складних мутацій, є зміни тауто­мерного стану нуклеотидных основ, які порушують характер їхнього спарювання. Сильне збудження коливань при безвипромінювальному дезбудженні ДНК, яка поглинула УФ-квант з триплетного електронного рівня енергії, спричинює зміни довжин водневих (Н) зв'язків між основами. Такі зміни мо­жуть відбуватися як у парах основ, утворюючих димери, так і в парах основ, які не є їхньою частиною. Скоріш за все, мутаційними є лише ті димери, в яких змінився таутомерний стан основ. У цьому й полягає одна з головних відмінностей пропонованої моделі від загальноприйнятої, де припускається, що з точки зору мутагенності всі димери однакові, а тільки ДНК-полімераза іноді помиляється, випадково вбудовуючи че­ком плементарні основи.

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