Biopolym. Cell. 2001; 17(5):347-355.
http://dx.doi.org/10.7124/bc.0005C4
Огляди
Регуляція генів інтерферонів І типу та інтерферон-індукованих генів. Зв'язок з вірусною репродукцією при ВІЛ-інфекції
1Карпов О. В.
  1. Інститут мікробіології і вірусології ім. Д. К. Заболотного НАН України
    вул. Академіка Заболотного, 154, Київ, Україна, 03680

Abstract

Здійснено порівняльний аналіз даних щодо одночасної участі групи клітинних та вірусних білкових транскрипційних факторів у регуляції індукованої експресії генів інтерферонів І типу (α- і β-ІФН), а також деяких ІФН-індукованих генів, з одного боку, та регуляції репродукції ВІЛ в інфікованих клітинах, – з іншого. Виходячи з наведених даних зроблено висновок стосовно доцільності пошуку шляхів терапевтичного втручання в перебіг ВІЛ-інфекції за допомогою модуляції рівнів певних транскрипційних факторів, пов'язаних з експресією генів ІФН І типу.
Повний текст: (PDF, українською)

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