Biopolym. Cell. 2001; 17(5):347-355.
http://dx.doi.org/10.7124/bc.0005C4
Reviews
Regulation of the type I interferon genes and interferon-inducible genes. The relationship with the viral reproduction under HIV-infection
1Karpov A. V.
  1. D. K. Zabolotny Institute of Microbiology and Virology, NAS of Ukraine
    154, Academika Zabolotnogo Str., Kyiv, Ukraine, 03680

Abstract

A comparative data analysis concerning the simultaneous participation of the group of cellular and viral protein transcription factors in the regulation of induced expression of the type I interferons (α- and β-IFNs) genes and some IFN-inducible genes as well as in the regulation of HIV reproduction in infected cells is given. On basis of the data presented the conclusion is made about the expediency of the search of the therapeutic ways influencing HIV-infection by modulation of the certain transcription factors involved in the type I IFN genes expression.
Full text: (PDF, in Ukrainian)

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