Biopolym. Cell. 2000; 16(6):530-539.
Геном та його регуляція
Отримання і характеристика гена миші, гомологічного Nnp-l
гену людини, картованому на ділянці хромосоми 21 q22.3
- Інститут молекулярної біології і генетики НАН України
Вул. Академіка Заболотного, 150, Київ, Україна, 03680 - Інститут Елеонори Рузвельт
2101 E. Уеслі пр., Денвер, Колорадо, США, 80208
Abstract
Отримано нову мишачу кДНК і ген, гомологічні гену нового
ядерного білка людини (NNP-І), картованому на ділянці 21-ї
хромосоми людини q22.3. Визначено їхню повну нуклеотидну
послідовність. Геномне секвенування показало, що ген Nnp-1
миші має 13 екзонів, розташованих на 14,5 тис. п. н. Визначено структуру гена NNP-І людини, здійснено порівняльній
аналіз генів NNP-І людини і миші Показано, що рівень
експресії гена Nnp-І в мозку миші не змінюється протягом
життя тварини, і експресія його в різних тканинах нормальних
та трисомних мишей ідентична.
Повний текст: (PDF, російською)
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