Biopolym. Cell. 2000; 16(6):530-539.
http://dx.doi.org/10.7124/bc.000594
Genome and Its Regulation
Identification and characterization of mouse homologue of human Nnp-I gene localized in 21q22.3
1Skripkina I. Ya., 1Tsyba L. A., 2Slavov D., 1Kvasha S. M., 2Gardiner K., 1Rynditch A. V.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. Eleanor Roosevelt Institute
    2101 E. Wesley Ave., Denver, CO, USA, 80208

Abstract

New mouse cDNA and gene homologous to human Novel Nuclear Protein (NNP-1) gene, mapped on q22.3 region of human chromosome 21, have been obtained and sequenced. Genomic sequencing has revealed that mouse Nnp-1 gene consisted of 13 exons distributed by 14.5 kb. The structure of human NNP-1 gene has been determined and comparative analysis of human and mouse NNP-1 genes has been fulfilled. It has been shown that the level of expression of mouse Nnp-1 gene in brain was not changed during the life cycle of the animal, and the expression of Nnp-1 gene in different tissues of normal and trisomic Ts65Dn mice were identical.
Full text: (PDF, in Russian)

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