Біологічна активність ліпополісахаридів грамнегативних бактерій

Здоровенко, Е. Л.; Позур, В. К.; Кучеренко, М. Є.

doi:10.7124/bc.000550

Biopolym. Cell. 2000; 16(1):5-15.

http://dx.doi.org/10.7124/bc.000550

Огляди

Біологічна активність ліпополісахаридів грамнегативних бактерій

1Здоровенко Е. Л., 1Позур В. К., 1Кучеренко М. Є.

Київський національний університет імені Тараса Шевченка
вул. Володимирська 64, Київ, Україна, 01033

Abstract

Ліпополісахариди (ЛПС, ендотоксини) – основний компонент клітинної стінки грамнегативних бактерій. В амфіпатичній макромолекулі ЛПС розрізняють ліпід А, коровий олігосахарид і О-специфічний ланцюг. Ендотоксини є біологічно активними молекулами. Вони можуть активувати синтез макрофагами запальних (фактор некрозу пухлин, інтерлейкіни (IL-1, IL-6, IL-8)) та протизапальних (IL-10) цитокінів, оксиду азоту, реакцію зв'язування комплементу, синтез антитіл, проявляти протипухлинну активність тощо. Окрім того, ЛПС мають і терапевтичне значення. Так, ЛПС (або окремі структурні компоненти їхніх макромолекул) здатні спричиню вати протективний ефект в разі септичного шоку. Є відомості стосовно успішного використання їх для лікування раку в людей.

Повний текст: (PDF, українською)

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