Biopolym. Cell. 1998; 14(4):371-380.
http://dx.doi.org/10.7124/bc.0004E1
Реакції йодування вуглеводного фрагмента піримідинових нуклеозидів як перспективний метод одержання протиретровірусних препаратів
1Шаламай А. С.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

Здійснено аналіз сучасних методів хімічного деоксигенування нуклеозидів, які пов'язані з реакціями нуклеофільного заміщення гідроксильних груп та β -елімінування проміжних активних синтоиів. Показано перспективність йодування вуглеводного залишку піримідинових нуклеозидів за допомогою йодфосфонісвих солей. Вивчено механізм деоксигенування. 5'-О-захищених похідних уридипу та тимінрибозиду, куди входять окремі реакції утворення С2~ та С3-квазіфосфонієвих йодидів, їхнє подальше внутрішньомолекулярне перетворення та β-елімінування 2',3'-дийодпохідних.
Повний текст: (PDF, українською)

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