Biopolym. Cell. 1998; 14(4):371-380.
http://dx.doi.org/10.7124/bc.0004E1
Iodination reaction of carbohydrate of pyrimidine nucleosides as perspective method preparation of antiretroviral drugs
1Shalamay A. S.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

A mechanism of iodination of C2 and C3 carbohydrate atoms in pyrimidine nucleosides has been studied. The iodination was established to be associated with step by step formation of intermediate quaziphosphtmic salts and with their further transformation under conditions of intramolecular nucleophilic reaction. The resulted' unstable 2',3'-diiodide was shown to be deiodinated and transformed into 2',3'-didehydro-2',3'-dideoxynucleoside.
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