Biopolym. Cell. 1998; 14(4):332-342.
http://dx.doi.org/10.7124/bc.0004DD
Полінуклеотидні інгібітори вірусної репродукції (алкіловані нуклеїнові кислоти, антисенсові РНК та рибозими)
1Швед А. Д.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

В огляді наведено дані власних робіт з вивчення поліну клеотид них інгібіторів вірусної репродукції. На моделях ДНК- та РНК-геномних вірусів показано противірусну активність ряду нуклеїнових кислот з різних природних джерел, а їхні алкіловані похідні виявилися значно ефективнішими інгібіторами вірусної репродукції. Ендогенний синтез антисенсових РНК забезпечував суттєве пригнічення репродукції ВІЛ-1 у культурах гемопоетичних клітин людини. Синтезовано та клоновано рибозим, здатний специфічно розрізати in vitro tat-PHK ВІЛ-I.
Повний текст: (PDF, українською)

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