Biopolym. Cell. 1998; 14(4):332-342.
http://dx.doi.org/10.7124/bc.0004DD
Polymicleothle inhibitors of virus reproduction (alkylated nucleic acids, antisensc RNAs and ribozyme)
1Shved A. D.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

The review contains previously obtained data on the experimental research of polynucieotide inhibitors of virus reproduction in models of RNA and DNA containing viruses. The antivirus properties of nucleic acids isolated from various sources were revealed, but their alkylated derivatives inhibited virus reproduction more efficiently The endogeneous synthesis of antisense RNA provided essential inhibition of HIV-I replication in human hematopoietic cell, cultures. The ribozyme capable to cleave specifically HIV-I tat RNA in vitro wits synthesized and cloned.
Full text: (PDF, in Ukrainian)

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