Biopolym. Cell. 1997; 13(6):445-452.
http://dx.doi.org/10.7124/bc.0004A5
Структура та функції біополімерів
Структурні особливості 6-азацитидину та його похідних: дані ПМР та 14 спектроскопії
1Самійленко С. П., 1Алексеева І. В., 1Пальчиківська Л. Г., 1Кондратюк І. В., 1Степанюгін А. В., 1Шаламай А. С., 1Говорун Д. М.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

Методами ІК спектроскопії та ПМР досліджено 6-azaCyt, 6-azaC та низку їхніх похідних і споріднених сполук. Дублетне розщеплення сигналу аміногрупи 6-azaCyt у спектрах ПМР, відсутнє в спектрах канонічної основи Суї та нуклеозидів С і dC за ідентичних умов експерименту, свідчить про більшу нееквівалентність амінопротонів, зумовлену більшою асиметрією електрон­ної будови, котра зростає при заміщенні кільця в положеннях 1 і 5 та підвищений бар'єр обертання аміногрупи. Низькопольова компонента дублету малочутлива до 5-метилзаміщення, що, очевидно, пов'язане із втягненням одного з амінопротонів у внутрішньомолекулярний Н-зв'язок з атомом N3. Показано зворотну (порівняно з Cyt) специфічність взаємодії 6-azaCyt щодо карбоксильної групи амінокислот та карбксилат-іона у безводному DMSO. Дані 14 спектроскопії підтверджують існування досліджених сполук з незаміщеною аміногрупою в DMSO та твердій фазі у формі кето-амінних таутомерів.
Повний текст: (PDF, українською)

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