Biopolym. Cell. 1990; 6(6):7-13.
Ефективність фільтрації у статистичних алгоритмах швидкого пошуку гомології
1Певзнер П. А.
  1. ВНДІ генетики та селекції промислових мікроорганізмів Главмікробіопрома при РМ СРСР
    Москва, СРСР

Abstract

При пошуку локальних гомологій (пошук гомологій у генетичних банках, вибір оптимальних олігонуклеотидних зондів і т. п.) виникає проблема його «пришвидчення». Квадратична трудомісткість алгоритмів динамічного програмування змушує вдаватися до методів фільтрації, що дозволяє швидко «відбракувати» послідовності з низьким рівнем гомології. У роботі вводиться поняття ефективності фільтрації і дається оцінка ефективності деяких фільтрів, при цьому показано, що в l-грамному аналізі ефективність фільтрації пов’язана з потенційним розширенням вихідного 4-літерного алфавіту.

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