Biopolym. Cell. 1990; 6(4):5-20.
http://dx.doi.org/10.7124/bc.000278
Дискусії
Білки, що самовідтворюються деякі наслідкиі прогнози
1Кордюм В. А.
  1. Інститут молекулярної біології і генетики АН УСРС
    Київ, СРСР

Abstract

Аналізується ситуація, що склалася в результаті останніх досліджень пріонів. Обгрунтовується припущення про те, що на додаток до відомої форми генетичного коду у вигляді первинної послідовності нуклеїнових кислот існує ще одна форма біологічної інформації – просторова структура білка, здатна до самовідтворення. Постулюється широке поширення в клітинах другої форми біологічного коду як основи життєдіяльності.
Повний текст: (PDF, російською)

References

[1] Weissmann C. Prions. Sheep disease in human clothing. Nature. 1989;338(6213):298-9.
[2] Prusiner SB. Prions. Sci Am. 1984;251(4):50-9.
[3] Kimberlin RH, Walker CA. Pathogenesis of scrapie in mice after intragastric infection. Virus Res. 1989;12(3):213-20.
[4] DeArmond SJ, McKinley MP, Barry RA, Braunfeld MB, McColloch JR, Prusiner SB. Identification of prion amyloid filaments in scrapie-infected brain. Cell. 1985;41(1):221-35.
[5] Brunori M, Silvestrini MC, Pocchiari M. The scrapie agent and the prion hypothesis. Trends Biochem Sci. 1988;13(8):309-13.
[6] Baum R. Scrapie gene found in healthy cells. Chem Eng News. 1985;63(18):34–6.
[7] Basler K, Oesch B, Scott M, Westaway D, Wälchli M, Groth DF, McKinley MP, Prusiner SB, Weissmann C. Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene. Cell. 1986;46(3):417-28.
[8] Narang HK. Scrapie, an unconventional virus: the current views. Proc Soc Exp Biol Med. 1987;184(4):375-88.
[9] Zuev VA. Slow viral infections of humans and animals. Moscow, Medicine, 1988; 256 p.
[10] Kretzschmar HA, Stowring LE, Westaway D, Stubblebine WH, Prusiner SB, Dearmond SJ. Molecular cloning of a human prion protein cDNA. DNA. 1986;5(4):315-24.
[11] Hsiao K, Baker HF, Crow TJ, Poulter M, Owen F, Terwilliger JD, Westaway D, Ott J, Prusiner SB. Linkage of a prion protein missense variant to Gerstmann-Sträussler syndrome. Nature. 1989;338(6213):342-5.
[12] Sytnik KM, Kordium VA, Kok IP. Regulatory mechanisms of the cell. Kyiv, Naukova Dumka, 1969; 152 p.
[13] Prusiner SB. Prion diseases and aging. J Cell. Biochem. 1989. Suppl. 13P:146.
[14] Heston LL, Morris ML. Family studies of Alzheimer's dementia: results and prospects. Can J Neurol Sci. 1986;13(4 Suppl):432-4.
[15] Haase AT. The pathogenesis of slow virus infections: molecular analyses. J Infect Dis. 1986;153(3):441-7.
[16] Edwards DD. On the Trail of the Alzheimer's Tragedy. Science News. 1985;128(24):374-5.
[17] Delabar JM, Goldgaber D, Lamour Y, DE Grouchy J, Sinet PM. Maladie d'Alzheimer et mongolisme sans trisomie 21, une même anomalie génétique: la duplication anormale du gène des plaques séniles cérébrales. Sem hop Paris. 1987; 63(24):1992-4.
[18] Dyrks T, Weidemann A, Multhaup G, Salbaum JM, Lemaire HG, Kang J, Müller-Hill B, Masters CL, Beyreuther K. Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. EMBO J. 1988;7(4):949-57.
[19] Lemaire HG, Salbaum JM, Multhaup G, Kang J, Bayney RM, Unterbeck A, Beyreuther K, Müller-Hill B. The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons. Nucleic Acids Res. 1989;17(2):517-22.
[20] McLachlan D. R. Aetiopathology of brain aging. Brain Pathol. 1984; 251-68.
[21] Delabar JM, Goldgaber D, Lamour Y, Nicole A, Huret JL, de Grouchy J, Brown P, Gajdusek DC, Sinet PM. Beta amyloid gene duplication in Alzheimer's disease and karyotypically normal Down syndrome. Science. 1987;235(4794):1390-2.
[22] Podlisny MB, Lee G, Selkoe DJ. Gene dosage of the amyloid beta precursor protein in Alzheimer's disease. Science. 1987;238(4827):669-71.
[23] Dorozynski A. Alzheimer: Ie gene du mongolisme serait en cause. Sci. et vie. 1987; 835(1):30-32.
[24] Kovacs D, Morandi A, Strocchi P. et al. Expression of the b-amyloid precursor portein gene in fibroblasts: a study of Alzheimer's disease and Down syndrome. BIOTECH RIA 88: Mol. probes: technol. and med. appl.: proc. Int. symp. Florence (Apr. 1-13, 1988): Abstr. New York, 1988:132.
[25] Tate-Ostroff B, Majocha RE, Marotta CA. Distribution of subdomains of the amyloid precursor protein in human brain tissue. Age. 1988; 11(4):179.
[26] Kitaguchi N, Takahashi Y, Tokushima Y, Shiojiri S, Ito H. Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity. Nature. 1988;331(6156):530-2.
[27] Marotta CA, Chou WG, Majocha RE. et al. Cells transfected with the amyloid gene and cloning of amyloid and fibrillary acidic protein variants of Alzheimer brain. Age. 1988; 11(4):179.
[28] Tanaka S, Nakamura S, Ueda K, Kameyama M, Shiojiri S, Takahashi Y, Kitaguchi N, Ito H. Three types of amyloid protein precursor mRNA in human brain: their differential expression in Alzheimer's disease. Biochem Biophys Res Commun. 1988;157(2):472-9.
[29] Octave JN, De Sauvage F, Macq AF, Maloteaux JM, Laterre EC. Identification of different β amyloid cDNAs cloned from the brain of a patient with sporadic alzheimer's disease. Neurochem Int. 1989;14(2):163-6.
[30] Vitek MP, Jacobsen JS, Donnelly RJ et al. Quantitative analysis of amyloid peptide precursor RNAs in Alzheimer's disease. J Cell Biochem. 1989; Suppl.13 :166.
[31] German TL, Marsh RF. The Scrapie Agent: A Unique Self-Replicating Pathogen. Prog Mol Subcell Biol. 1983;111–21.
[32] Wills PR. Scrapie, ribosomal proteins and biological information. J Theor Biol. 1986;122(2):157-78.
[33] Westaway D, Goodman PA, Mirenda CA, McKinley MP, Carlson GA, Prusiner SB. Distinct prion proteins in short and long scrapie incubation period mice. Cell. 1987;51(4):651-62.
[34] Maddox J. Further anxieties about AIDS. Nature. 1986 Jan 2-8;319(6048):9.
[35] Haseltine WA, Patarca R. AIDS virus and scrapie agent share protein. Nature. 1986 Sep 11-17;323(6084):115-6.
[36] Fernando Bazan J, Fletterick RJ, Prusiner SB. AIDS virus and scrapie protein genes. Nature. 1987 Feb 12-18;325(6105):581.
[37] Braun MJ, Gonda MA, George DG, Bazan JF, Fletterick RJ, Prusiner SB. The burden of proof in linking AIDS to scrapie. Nature. 1987 Dec 10-16;330(6148):525-6.
[38] Carlson GA, Kingsbury DT, Goodman PA, Coleman S, Marshall ST, DeArmond S, Westaway D, Prusiner SB. Linkage of prion protein and scrapie incubation time genes. Cell. 1986;46(4):503-11.
[39] Pain S. Scrapie agent gains a genome. New Sci. 1987; 113(1545):32.
[40] Fraser H. A review of experimental scrapie and its relevance to Alzheimer's disease. Age and Ageing. 1984; 13(3):184-5.
[41] Roberts JD, Kunkel TA. Fidelity of a human cell DNA replication complex. Proc Natl Acad Sci U S A. 1988;85(19):7064-8.
[42] Tsekov N. Earth's population - projections in the past and the future. Geography. 1988 42(7):1-4.
[43] Ghezzi A, Zaffaroni M, Marforio S, Montanini R, Cazzullo CL, Allegranza A. Two familial cases of Creutzfeldt-Jakob disease in Italy. Ital J Neurol Sci. 1989;10(2):199-202.
[44] Collinge J, Harding AE, Owen F, Poulter M, Lofthouse R, Boughey AM, Shah T, Crow TJ. Diagnosis of Gerstmann-Sträussler syndrome in familial dementia with prion protein gene analysis. Lancet. 1989;2(8653):15-7.
[45] Lewin PK. Infectious peptides: postulated mechanisms of protovirin replication in scrapie. Can Med Assoc J. 1982;127(6):471-2.