Biopolym. Cell. 1989; 5(2):26-36.
Дискусії
Перенесення генів у клітини ссавців за допомогою ретровірусних векторів
1Томілін Н. В., 2Кавсан В. М.
  1. Інститут цитології АН СРСР
    Ленінград, СРСР
  2. Інститут молекулярної біології і генетики АН УСРС
    Київ, СРСР

Abstract

Представлено огляд робіт з конструювання векторів для перенесення генів у клітини ссавців на основі ретровірусного геному. Обговорюються переваги і недоліки таких систем за використання в генній терапії людини.

References

[1] Wigler M, Sweet R, Sim GK, Wold B, Pellicer A, Lacy E, et al. Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell. 1979;16(4):777–85.
[2] Tomilin NV. New genetic transformation system of the mammals somatic cells. Biotekhnologiia. 1987. 3(3):343-351.
[3] Parkman R. The application of bone marrow transplantation to the treatment of genetic diseases. Science. 1986;232(4756):1373-8.
[4] Gruber HE, Finley KD, Hershberg RM, Katzman SS, Laikind PK, Seegmiller JE, Friedmann T, Yee JK, Jolly DJ. Retroviral vector-mediated gene transfer into human hematopoietic progenitor cells. Science. 1985;230(4729):1057-61.
[5] Wyke JA, Stoker AW, Searle S, Spooncer E, Simmons P, Dexter TM. Perturbed hemopoiesis and the generation of multipotential stem cell clones in src-infected bone marrow cultures is an indirect or transient effect of the oncogene. Mol Cell Biol. 1986;6(3):959-63.
[6] Magli MC, Dick JE, Huszar D, Bernstein A, Phillips RA. Modulation of gene expression in multiple hematopoietic cell lineages following retroviral vector gene transfer. Proc Natl Acad Sci U S A. 1987;84(3):789-93.
[7] Khesin RB. Genome instability. Moscow, Nauka, 1984; 472 p.
[8] Yu SF, von R?den T, Kantoff PW, Garber C, Seiberg M, R?ther U, Anderson WF, Wagner EF, Gilboa E. Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells. Proc Natl Acad Sci U S A. 1986;83(10):3194-8.
[9] Mann R, Mulligan RC, Baltimore D. Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell. 1983;33(1):153-9.
[10] Cepko CL, Roberts BE, Mulligan RC. Construction and applications of a highly transmissible murine retrovirus shuttle vector. Cell. 1984;37(3):1053-62.
[11] Dick JE, Magli MC, Huszar D, Phillips RA, Bernstein A. Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/Wv mice. Cell. 1985;42(1):71-9.
[12] Cone RD, Reilly EB, Eisen HN, Mulligan RC. Tissue-specific expression of functionally rearranged lambda 1 Ig gene through a retrovirus vector. Science. 1987;236(4804):954-7.
[13] Yamada G, Kitamura Y, Sonoda H, Harada H, Taki S, Mulligan RC, Osawa H, Diamantstein T, Yokoyama S, Taniguchi T. Retroviral expression of the human IL-2 gene in a murine T cell line results in cell growth autonomy and tumorigenicity. EMBO J. 1987;6(9):2705-9.
[14] Miller AD, Eckner RJ, Jolly DJ, Friedmann T, Verma IM. Expression of a retrovirus encoding human HPRT in mice. Science. 1984;225(4662):630-2.
[15] Hock RA, Miller AD. Retrovirus-mediated transfer and expression of drug resistance genes in human haematopoietic progenitor cells. Nature. 1986 Mar 20-26;320(6059):275-7.
[16] Belmont JW, Henkel-Tigges J, Chang SM, Wager-Smith K, Kellems RE, Dick JE, Magli MC, Phillips RA, Bernstein A, Caskey CT. Expression of human adenosine deaminase in murine haematopoietic progenitor cells following retroviral transfer. Nature. 1986 Jul 24-30;322(6077):385-7.
[17] Sorrentino V, Drozdoff V, McKinney MD, Zeitz L, Fleissner E. Potentiation of growth factor activity by exogenous c-myc expression. Proc Natl Acad Sci U S A. 1986;83(21):8167-71.
[18] Keller G, Paige C, Gilboa E, Wagner EF. Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors. Nature. 1985 Nov 14-20;318(6042):149-54.
[19] Kantoff PW, Kohn DB, Mitsuya H, Armentano D, Sieberg M, Zwiebel JA, Eglitis MA, McLachlin JR, Wiginton DA, Hutton JJ, et al. Correction of adenosine deaminase deficiency in cultured human T and B cells by retrovirus-mediated gene transfer. Proc Natl Acad Sci U S A. 1986;83(17):6563-7.
[20] Wolff JA, Yee JK, Skelly HF, Moores JC, Respess JG, Friedmann T, Leffert H. Expression of retrovirally transduced genes in primary cultures of adult rat hepatocytes. Proc Natl Acad Sci U S A. 1987;84(10):3344-8.
[21] Stewart CL, Schuetze S, Vanek M, Wagner EF. Expression of retroviral vectors in transgenic mice obtained by embryo infection. EMBO J. 1987;6(2):383-8.
[22] Miller AD, Ong ES, Rosenfeld MG, Verma IM, Evans RM. Infectious and selectable retrovirus containing an inducible rat growth hormone minigene. Science. 1984;225(4666):993-8.
[23] Emerman M, Temin HM. Genes with promoters in retrovirus vectors can be independently suppressed by an epigenetic mechanism. Cell. 1984;39(3 Pt 2):449-67.
[24] Milewski EA. Discussions on human gene therapy. Recomb DNA Tech Bull. 1986;9(2):88-130.
[25] The metabolic basis of inherited disease. New York: McGrow Hill, 1983. 450 p.
[26] Joyner A, Keller G, Phillips RA, Bernstein A. Retrovirus transfer of a bacterial gene into mouse haematopoietic progenitor cells. Nature. 1983 Oct 6-12;305(5934):556-8.
[27] Williams DA, Lemischka IR, Nathan DG, Mulligan RC. Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse. Nature. 1984 Aug 9-15;310(5977):476-80.
[28] Narayanan R, Jastreboff MM, Bertino JR. Development of an amphotropic, high-titer retrovirus vector expressing the dihydrofolate reductase gene and conferring methotrexate resistance. Gene. 1986;48(1):71-80.
[29] Kwok WW, Schuening F, Stead RB, Miller AD. Retroviral transfer of genes into canine hemopoietic progenitor cells in culture: a model for human gene therapy. Proc Natl Acad Sci U S A. 1986;83(12):4552-5.
[30] Deeg H, Storb R, Thomas ED. Recent advances in bone morrow transplantation. New York: Alan R. Liss, 1983. 546 p.
[31] McComick D. Human gene therapy: the first round. Biotechnology. 1985;3(8):689-93.
[32] Engineering in humans. Biotechnology Can Res. 1986. 19(6):6.
[33] Grunwald DJ, Dale B, Dudley J, Lamph W, Sugden B, Ozanne B, Risser R. Loss of viral gene expression and retention of tumorigenicity by Abelson lymphoma cells. J Virol. 1982;43(1):92-103.
[34] Rynditch AV, Gerik I, Lgotak V, Yatsula BA, Svoboda Ya. Absence of the avian sarcoma virus genes in the transformed mammalian cells. Biopolym Cell. 1985; 1(2):92-8.
[35] Rynditch A, Yatsula B, Hlozanck I, Svoboda J. Instability of ASV genomes structure in mammalian and duck cells. 17th FEBS meeting: Abstr. Berlin, 1986. Vol. 367:226.
[36] Robertson M. Mapping the disease phenotype. Nature. 1987;327(6121):372–3.
[37] Lee WH, Bookstein R, Hong F, Young LJ, Shew JY, Lee EY. Human retinoblastoma susceptibility gene: cloning, identification, and sequence. Science. 1987;235(4794):1394-9.
[38] White R. The search for the cystic fibrosis gene. Science. 1986;234(4780):1054-5.