Biopolym. Cell. 2025; 41(1):63-76.
http://dx.doi.org/10.7124/bc.000B10
Дискусії
МСК – центральний елемент системи збереження–реставрації
1Кордюм В. А., 1Іродов Д. М.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03143

Abstract

Широке вивчення МСК як терапевтичних агентів виявило широкий спектр різноманітних механізмів їх взаємодії з іншими клітинами. Виявилося, що МСК активно взаємодіють не тільки з клітинами імунної системи, модулюючи, наприклад, запальну реакцію, але і з клітинами пошкоджених або змінених тканин, підтримуючи їх і запускаючи процеси загоєння і регенерації. До цього часу вивчення та використання МСК відбувалося в основному після їх розширення ex vivo. Однак через високу епігеномну пластичність цих клітин, залежну від сигналів навколишнього середовища, при культивуванні ex vivo ці клітини мають час змінитися настільки, що це не дозволяє прямої екстраполяції ефектів, які вони демонструють, для розуміння їхньої природної ролі в природних умовах. Тим не менш, на основі сукупності вже отриманих даних, ми робимо провокативне припущення про центральне місце МСК у забезпеченні процесів відновлення/регенерації в організмі. Крім того, слід зазначити, що не всі описані на сьогоднішній день ефекти вписуються в усталену парадигму клітинного поділу за функціональною ознакою, оскільки феномен МСК – це скоріше не тип клітини, а стан, в який можуть переходити різні високопластичні клітини, що оточують судини. пропуск. Це свідчить про можливу необхідність перегляду деяких усталених концепцій і може призвести до виділення забезпечення реставраційних/репараційних процесів в окрему систему збереження та реставрації організму.
Keywords: МСК, відновлення клітин, мезенхімальні клітини збереження і відновлення
Повний текст: (PDF, англійською)

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