Biopolym. Cell. 2020; 36(6):409-422.
http://dx.doi.org/10.7124/bc.000A3F
Огляди
Білкові агрегати як носії негенетичної пам’яті у бактерій після стресу
1Кухаренко О. Є., 1, 2Терзова В. О., 1Зубова Г. В.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03143
  2. Національний університет «Києво-Могилянська академія»
    вул. Г. Сковороди 2, Київ, Україна, 04655

Abstract

Агрегування білків пов’язане з утворенням олігомерів і комплексів, що призводять до порушень клітинних процесів. Утворення білкових агрегатів асоціюється з патологіями та старінням у еукаріотів, тоді як у бактерій цей процес викликає різкі зміни швидкості росту, стійкості до стресу і вірулентності.Проте, за певних обставин ці агрегати відіграють функціональнуроль. Фактори навколишнього середовища та внутрішньоклітинні фактори посилюють пошкодження білка за рахунок його скупчення, тим не менш, за сублетальних доз протеотоксичних стресових факторів навколишнього середовища, білкові агрегати можуть покращувати стійкість клітин та зберігати механізмиепігенетичної пам’яті про дію попередніх стресорів протягом декількох поколінь. Наведені дані про агреговані білки, що мають ознаки негенетичного (епігенетичного) спадкування, показують, що успадкування на основі білка відомо в усіх трьох царствах живих організмів. У цьому огляді увагу акцентовано на білкових агрегатах як носіях негенетичної пам’яті бактерій.
Keywords: білкові агрегати, бактерії, стрес, епігенетичне спадкування
Повний текст: (PDF, англійською)

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