Biopolym. Cell. 2020; 36(3):163-181.
http://dx.doi.org/10.7124/bc.000A23
Огляди
Кільцеві РНК – “кільця влади” над клітиною
1Гордіюк В. В., 1Маньковська О. С.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03143

Abstract

Кiльцеві РНК (circRNA) є ендогенними ковалентнозамкненими одноланцюговиминекодуючими РНК (ncRNA), що не мають 5′-КЭПа і 3′-поліаденілювання, які утворюються внаслідок різних варіацій альтернативного сплайсингу мРНК. Експресію кільцевих РНК було виявлено у представників усіх груп еволюційного дерева життя, включаючи віруси та прокаріоти. Ці молекули є еволюційно консервативними. Кільцеві РНК відіграють постійну і універсальну біологічну роль. У даному огляді ми узагальнили останню наявну інформацію про кільцеві РНК та виділили їх найважливіші та найкраще вивчені функції в різних біологічних процесах.
Keywords: Кільцеві РНК (circRNA), РНК-звязувальні білки (RBPs), модель бэкс плайсинга, модель лассо, циркулююча позаклітинна РНК, circRNA, асоційовани з раком.
Повний текст: (PDF, англійською)

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