Biopolym. Cell. 2019; 35(4):249-267.
Огляди
Фотосенсибілізаторина основі наночастин з ефектом агрегаційно-індукованої емісії
1Корнеев О. В., 2Сахно Т. В., 2Короткова І. В.
- Вищий державний навчальний заклад України «Українска медична стоматологічна академія»
вул. Шевченко, 23, Полтава, Україна, 36024 - Полтавська державна аграрна академія
вул. Сковороди, 1/3, Полтава, Україна, 36000
Abstract
Фотодинамічна терапія (ФТД) – це метод лікування локалізованих видів раку, що заснований на фотохімічній реакції між активованою світлом молекулою або фотосенсибілізатором (ФС), світлом і молекулярним киснем. Вирішальне значення для забезпечення ефективності ФДТ має правильно обраний ФС. Незважаючи на численні дослідження в цьому напрямку, більшість відомих ФС мають ряд недоліків, такі як відсутність специфічності і агрегація в водних середовищах. Отже, пошук ідеального ФС – актуальне завдання для подальшого розвитку ФДТ. У цьому огляді представлено класифікацію і аналізуються основні особливості ФС різних поколінь, описано механізми їх дії. Обговорюються різні способи здійснення адресної доставки ФС до пухлинних клітин. Описано переваги наночастин ФС з ефектом агрегаційно-індукованої емісії (АІЕ) відносно вихідних фотосенсибілізаторів.Показана можливість використання таких світловипромінюючих структур для практичного застосування в фототерапії раку.
Keywords: фотодинамічна терапія, фотосенсибілізатор, агрегаційно-індукована емісія
Повний текст: (PDF, англійською)
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