Biopolym. Cell. 2017; 33(6):463-472.
http://dx.doi.org/10.7124/bc.000969
Дискусії
Пусковий ефект «терапевтичних МСК»
1Кордюм В. А., 1Іродов Д. М., 2Чайковський Ю. В.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680
  2. Національний медичний університет імені О. О. Богомольця
    13, бульв. Тараса Шевченка, Київ, Україна, 01601

Abstract

Використання МСК як терапевтичного препарату не завжди виявляється високоефективним. У статті аналізуються можливі причини такої дії МСК і обґрунтовується концепція їх «пускового ефекту». Він полягає в тому, що сигнальні молекули, що виділяються МСК, що вводяться в організм, з одного боку зменшують ступінь ураження клітин, підтримуючи і відновлюючи пошкоджені клітини, а з іншого - призводять до мобілізації і активації власних (резидентних) СК, що в подальшому реалізують заміщення уражених клітин. Реалізація власне терапевтичного ефекту залежить від наявності або відсутності генетично детермінованих порушень.
Keywords: мезинхімальні стовбурові клітини, пусковий ефект, мобілізація, активація
Повний текст: (PDF, англійською)

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