Biopolym. Cell. 2017; 33(5):393-400.
Молекулярна Біомедицина
Визначення асоціації носійства генетичних поліморфізмів з мутаційним статусом генів BRCA1/2 при спонтанному раку молочної залози
1Поліник С. І., 1Рибченко Л. А., 1Клименко С. В., 2Захарцева Л. М., 3Клімук Б. Т.
  1. Державна установа "Національний науковий центр радіаційної медицини НАМН України
    вул. Мельникова 53, Київ, Україна, 04050
  2. Національний медичний університет імені О. О. Богомольця
    13, бульв. Тараса Шевченка, Київ, Україна, 01601
  3. Національний технічний університет України "Київський політехнічний інститут імені Ігоря Сікорського"
    пр-т Перемоги, 37, Київ, Україна, 03056

Abstract

Мета. Визначення асоціації носійства генетичних поліморфізмів генів FGFR2, TOX3/LOC643714 з мутаційним статусом генів BRCA1/2 у жінок України хворих на рак молочної залози, які не мають впливу іонізуючого випромінювання в анамнезі. Методи. Молекулярно-генетичні методи дослідження. Непараметричні дані оцінювали з використанням точного тесту Фішера в двобічному варіанті. Статистичний аналіз проводили з використанням пакету програми StatPlus Pro. Результати. Показано,що існують асоціації носійства генетичних поліморфізмів rs2981582 гена FGFR2, rs3803662 гена TOX3/LOC643714 з мутаційним статусом генів BRCA1/2 жінок хворих на РМЗ без іонізуючого випромінювання в анамнезі. Висновки. Серед досліджених генетичних поліморфізмів достовірним виявили асоціацію між мінорним генотипом ТТгена TOX3/LOC643714 та позитивним статусом гена BRCA1. Не знайдено статистичної асоціації серед гомозигот за мажорними алелями та гетерозигот поліморфізмів генів FGFR2, TOX3/LOC643714, з наявністю або відсутністю мутацій BRCA1/2 (p < 0,05).
Keywords: рак молочної залози, генетичні поліморфізми, мутації BRCA1/2

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