Biopolym. Cell. 2017; 33(5):393-400.
Молекулярна Біомедицина
Визначення асоціації носійства генетичних поліморфізмів з мутаційним статусом генів BRCA1/2 при спонтанному раку молочної залози
- Державна установа "Національний науковий центр радіаційної медицини НАМН України
вул. Мельникова 53, Київ, Україна, 04050 - Національний медичний університет імені О. О. Богомольця
13, бульв. Тараса Шевченка, Київ, Україна, 01601 - Національний технічний університет України "Київський політехнічний інститут імені Ігоря Сікорського"
пр-т Перемоги, 37, Київ, Україна, 03056
Abstract
Мета. Визначення асоціації носійства генетичних поліморфізмів генів FGFR2, TOX3/LOC643714 з мутаційним статусом генів BRCA1/2 у жінок України хворих на рак молочної залози, які не мають впливу іонізуючого випромінювання в анамнезі. Методи. Молекулярно-генетичні методи дослідження. Непараметричні дані оцінювали з використанням точного тесту Фішера в двобічному варіанті. Статистичний аналіз проводили з використанням пакету програми StatPlus Pro. Результати. Показано,що існують асоціації носійства генетичних поліморфізмів rs2981582 гена FGFR2, rs3803662 гена TOX3/LOC643714 з мутаційним статусом генів BRCA1/2 жінок хворих на РМЗ без іонізуючого випромінювання в анамнезі. Висновки. Серед досліджених генетичних поліморфізмів достовірним виявили асоціацію між мінорним генотипом ТТгена TOX3/LOC643714 та позитивним статусом гена BRCA1. Не знайдено статистичної асоціації серед гомозигот за мажорними алелями та гетерозигот поліморфізмів генів FGFR2, TOX3/LOC643714, з наявністю або відсутністю мутацій BRCA1/2 (p < 0,05).
Keywords: рак молочної залози, генетичні поліморфізми, мутації BRCA1/2
Повний текст: (PDF, англійською)
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