Інтерактом скафолдного білка інвадоподій TKS5

Кропивко, С. В.

doi:10.7124/bc.0008FE

Biopolym. Cell. 2015; 31(6):417-421.

http://dx.doi.org/10.7124/bc.0008FE

Мініогляди

Інтерактом скафолдного білка інвадоподій TKS5

1Кропивко С. В.

Інститут молекулярної біології і генетики НАН України
Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

TKS5 скафолдний білок, який приймає участь у функціонуванні інвадоподій та продукції активних форм кисню (ROS). TKS5 критично важливий компонент інвадоподій оскільки за його відсутності ракові клітини втрачають можливість утворювати ці структури інвазивності. Він фосфорилюється SRC-кіназою в наслідок чого взаємодіє з фосфотидилінозитид фосфатами мембрани запускаючи процес утворення інвадоподій. На більш пізніх етапах TKS5 регулює реорганізацію актинового цитоскелету та деградацію позаклітинного матриксу. TKS5 також регулює продукцію ROS, які є важливими регуляторами сигналів різноманітних клітинних функцій

Keywords: TKS5, інтерактом, інвадоподія, скафолдний білок

Повний текст: (PDF, англійською)

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