Biopolym. Cell. 2015; 31(6):417-421.
http://dx.doi.org/10.7124/bc.0008FE
Мініогляди
Інтерактом скафолдного білка інвадоподій TKS5
1Кропивко С. В.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

TKS5 скафолдний білок, який приймає участь у функціонуванні інвадоподій та продукції активних форм кисню (ROS). TKS5 критично важливий компонент інвадоподій оскільки за його відсутності ракові клітини втрачають можливість утворювати ці структури інвазивності. Він фосфорилюється SRC-кіназою в наслідок чого взаємодіє з фосфотидилінозитид фосфатами мембрани запускаючи процес утворення інвадоподій. На більш пізніх етапах TKS5 регулює реорганізацію актинового цитоскелету та деградацію позаклітинного матриксу. TKS5 також регулює продукцію ROS, які є важливими регуляторами сигналів різноманітних клітинних функцій
Keywords: TKS5, інтерактом, інвадоподія, скафолдний білок
Повний текст: (PDF, англійською)

References

[1] Balla T. Inositol-lipid binding motifs: signal integrators through protein-lipid and protein-protein interactions. J Cell Sci. 2005;118(Pt 10):2093-104.
[2] Reebye V, Frilling A, Hajitou A, Nicholls JP, Habib NA, Mintz PJ. A perspective on non-catalytic Src homology (SH) adaptor signalling proteins. Cell Signal. 2012;24(2):388-92.
[3] Lock P, Abram CL, Gibson T, Courtneidge SA. A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate. EMBO J. 1998;17(15):4346-57.
[4] Murphy DA, Courtneidge SA. The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function. Nat Rev Mol Cell Biol. 2011;12(7):413-26.
[5] Seals DF, Azucena EF Jr, Pass I, Tesfay L, Gordon R, Woodrow M, Resau JH, Courtneidge SA. The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells. Cancer Cell. 2005;7(2):155-65.
[6] Stylli SS, I ST, Kaye AH, Lock P. Prognostic significance of Tks5 expression in gliomas. J Clin Neurosci. 2012;19(3):436-42.
[7] Stylli SS, Luwor RB, Kaye AH, I ST, Hovens CM, Lock P. Expression of the adaptor protein Tks5 in human cancer: prognostic potential. Oncol Rep. 2014;32(3):989-1002.
[8] Pan YR, Cho KH, Lee HH, Chang ZF, Chen HC. Protein tyrosine phosphatase SHP2 suppresses podosome rosette formation in Src-transformed fibroblasts. J Cell Sci. 2013;126(Pt 2):657-66.
[9] Oikawa T, Oyama M, Kozuka-Hata H, Uehara S, Udagawa N, Saya H, Matsuo K. Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell-cell fusion. J Cell Biol. 2012;197(4):553-68.
[10] Tsujita K, Itoh T. Phosphoinositides in the regulation of actin cortex and cell migration. Biochim Biophys Acta. 2015;1851(6):824-31.
[11] Abram CL, Seals DF, Pass I, Salinsky D, Maurer L, Roth TM, Courtneidge SA. The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. J Biol Chem. 2003;278(19):16844-51.
[12] Yamaguchi H, Oikawa T. Membrane lipids in invadopodia and podosomes: key structures for cancer invasion and metastasis. Oncotarget. 2010;1(5):320-8.
[13] Oikawa T, Itoh T, Takenawa T. Sequential signals toward podosome formation in NIH-src cells. J Cell Biol. 2008;182(1):157-69.
[14] Crimaldi L, Courtneidge SA, Gimona M. Tks5 recruits AFAP-110, p190RhoGAP, and cortactin for podosome formation. Exp Cell Res. 2009;315(15):2581-92.
[15] Oikawa T, Matsuo K. Possible role of IRTKS in Tks5-driven osteoclast fusion. Commun Integr Biol. 2012;5(5):511-5.
[16] Oser M, Yamaguchi H, Mader CC, Bravo-Cordero JJ, Arias M, Chen X, Desmarais V, van Rheenen J, Koleske AJ, Condeelis J. Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. J Cell Biol. 2009;186(4):571-87.
[17] Stylli SS, Stacey TT, Verhagen AM, Xu SS, Pass I, Courtneidge SA, Lock P. Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation. J Cell Sci. 2009;122(Pt 15):2727-40.
[18] Lányi Á, Baráth M, Péterfi Z, Bogel G, Orient A, Simon T, Petrovszki E, Kis-Tóth K, Sirokmány G, Rajnavölgyi É, Terhorst C, Buday L, Geiszt M. The homolog of the five SH3-domain protein (HOFI/SH3PXD2B) regulates lamellipodia formation and cell spreading. PLoS One. 2011;6(8):e23653.
[19] Rufer AC, Rumpf J, von Holleben M, Beer S, Rittinger K, Groemping Y. Isoform-selective interaction of the adaptor protein Tks5/FISH with Sos1 and dynamins. J Mol Biol. 2009;390(5):939-50.
[20] Oser M, Dovas A, Cox D, Condeelis J. Nck1 and Grb2 localization patterns can distinguish invadopodia from podosomes. Eur J Cell Biol. 2011;90(2-3):181-8.
[21] Kropyvko SV. New partners of TKS4 scaffold protein. Biopolym Cell. 2015; 31(5):395–401.
[22] Bisson N, James DA, Ivosev G, Tate SA, Bonner R, Taylor L, Pawson T. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. Nat Biotechnol. 2011;29(7):653-8.
[23] Thompson O, Kleino I, Crimaldi L, Gimona M, Saksela K, Winder SJ. Dystroglycan, Tks5 and Src mediated assembly of podosomes in myoblasts. PLoS One. 2008;3(11):e3638.
[24] Endo T. Dystroglycan glycosylation and its role in alpha-dystroglycanopathies. Acta Myol. 2007;26(3):165-70.
[25] Seals DF, Courtneidge SA. The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev. 2003;17(1):7-30.
[26] Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev. 2007;87(1):245-313.
[27] Weaver AM. Regulation of cancer invasion by reactive oxygen species and Tks family scaffold proteins. Sci Signal. 2009;2(88):pe56.
[28] Wu WS. The signaling mechanism of ROS in tumor progression. Cancer Metastasis Rev. 2006;25(4):695-705.
[29] Diaz B, Shani G, Pass I, Anderson D, Quintavalle M, Courtneidge SA. Tks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation. Sci Signal. 2009;2(88):ra53.
[30] Gianni D, Diaz B, Taulet N, Fowler B, Courtneidge SA, Bokoch GM. Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. Sci Signal. 2009;2(88):ra54.
[31] Brandes RP, Weissmann N, Schröder K. Nox family NADPH oxidases: Molecular mechanisms of activation. Free Radic Biol Med. 2014;76:208-26.
[32] Gianni D, DerMardirossian C, Bokoch GM. Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation. Eur J Cell Biol. 2011;90(2-3):164-71.
[33] Kawada K, Upadhyay G, Ferandon S, Janarthanan S, Hall M, Vilardaga JP, Yajnik V. Cell migration is regulated by platelet-derived growth factor receptor endocytosis. Mol Cell Biol. 2009;29(16):4508-18.
[34] Moodley S, Hui Bai X, Kapus A, Yang B, Liu M. XB130/Tks5 scaffold protein interaction regulates Src-mediated cell proliferation and survival. Mol Biol Cell. 2015;26(24):4492-502.
[35] Bai XH, Cho HR, Moodley S, Liu M. XB130-A Novel Adaptor Protein: Gene, Function, and Roles in Tumorigenesis. Scientifica (Cairo). 2014;2014:903014.