Biopolym. Cell. 2014; 30(5):349-357.
Огляди
Молекулярні механізми багатосторонньої біологічної
активності інтерлейкіну-7
1Сливка А. В., 2Окунєв О. В.
- Навчально-науковий центр «Інститут біології»
Київського національного університету імені Тараса Шевченка
вул. Володимирська, 64/13, Київ, Україна, 01601 - Інститут молекулярної біології і генетики НАН України
вул. Академіка Заболотного, 150, Київ, Україна, 03680
Abstract
У результаті імунологічних досліджень останніх 25 років показано, що інтерлейкін-7 (ІЛ-7) є одним з найважливіших регуляторних цитокінів імунної системи. Він чинить значний вплив на розвиток, проліферацію і активацію імунних клітин, однак не належить до класичних цитокінів-активаторів, як, наприклад, ІЛ- 2, оскільки багато типів клітин потребують його присутності майже на всіх стадіях розвитку, а спектр його активностей є вражаючим. Цей огляд має на меті узагальнити численні дані щодо структури ІЛ-7, його біологічної активності і особливостей функціонування in vitro та in vivo. Основний акцент зроблено на шляхах сигнальної трансдукції ІЛ-7, які визначають долю Т- і В-клітин, а також деяких інших клітин, важливих для підтримання гомеостазу організму. Аналіз літератури цієї сфери, на нашу думку, не лише виявив низку питань, які наразі не мають відповідей, але й окреслив напрямки для майбутніх досліджень.
Keywords: цитокін, імунна система, сигнальна трансдукція, регуляція.
Повний текст: (PDF, англійською)
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