Biopolym. Cell. 2014; 30(4):260-272.
http://dx.doi.org/10.7124/bc.00089F
Огляди
Фактор транскрипції CTCF і організація геному ссавців
1Котова О. С., 1Акопов С. Б., 1Свердлов Є. Д., 1Ніколаєв Л. Г.
  1. Установа Російської академії наук Інститут біоорганічної хімії імені академіків М. М. Шемякіна і Ю. А. Овчинникова РАН
    вул. Миклухо-Маклая, 16/10, Москва, Російська Федерація, 117997

Abstract

Фактор транскрипції CTCF вважають одним з основних учасни- ків різних мереж регуляції генів, з-поміж яких активація і репресія транскрипції, утворення незалежно функціонуючих доменів хроматину, регуляція імпринтингу тощо. Секвенування геномів людини та інших организмів дозволяє виявляти геномний розподіл сайтів зв’язування CTCF та ідентифікувати CTCF-залежні регуляторні елементи, до яких належать інсулятори. В огляді підсумовано нові дані з функціонування CTCF у рамках гіпотези участі петельних доменів хроматину у великомасштабній регуляції активності геному. Фундаментальні властивості CTCF дозволяють йому діяти як регулятор транскрипції, інсуляторний білок, а також як розподілений по геному прикордонний елемент,здатний залучати різні фактори, які з’являються у відповідь на різноманітні зовнішні та внутрішні чинники і таким чином виконувати свої сигнал-специфічні функції.
Keywords: фактор транскрипції CTCF, хроматин, регуляція транскрипції
Повний текст: (PDF, російською) (PDF, англійською)

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