Biopolym. Cell. 2014; 30(4):249-259.
http://dx.doi.org/10.7124/bc.00089E
Огляди
Сателітна ДНК і пов’язані хвороби
1Річ Ж., 1Огризько В. В., 1Пірожкова І. В.
  1. Інститут Густава Русі
    вул. Едуарда Вальян, 114, Вільжюіф, Франція, 94805

Abstract

Сателітна ДНК, також відома як тандемно повторювана ДНК, складається з кластерів повторюваних послідовностей, об’єднаних у широкий клас часто повторюваних елементів. Сателітнi ДНК можна розділити на декілька класів залежно від розміру ок- ремого повтора: мікросателітні, мінісателітні, мідісателітні і макросателітні ДНК. Сателітну ДНК спочатку розглядали як «сміттєву». Лише зовсім недавно таку концепцію було переглянуто і наразі сателітну ДНК відносять до ДНК, якій притаманні різні функції. Крім того, присутність у геномі повторюваних послідовностей пов’язана з високою частотою мутацій, епігенетичними змінами і модифікаціями в профілі експресії генів, що потенційно може призвести до різних патологій. Таким чином, вивчення сателітної ДНК буде корисним при розробці терапії, спрямованої на лікування захворювань, пов’язаних iз сателітною ДНК, таких як м’язова дистрофія FSHD, неврологічні патології, хвороби, обумовлені порушеннями розвитку, та онкологічні захворювання.
Keywords: сателітна ДНК, повторювані послідовності, частота мутацій, захворювання, пов’язані із сателітною ДНК.
Повний текст: (PDF, англійською)

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