Biopolym. Cell. 2014; 30(3):184-189.
http://dx.doi.org/10.7124/bc.000894
Мініогляди
Механізми активації мономерних рецепторів цитокінів: ліганд-незалежна та ліганд-індукавана димеризація
1, 2Гришкова В. С., 3Албу Р. І., 1, 2Константинеску С. Н.
  1. Людвіговскій інститут дослідження раку, Брюссельський філія
    пр-т Гіппократа 74, Bte B1.74.03, Брюссель, BRU, Бельгія, 1200
  2. Католицький університет Левена, де Дюв Інститут
    пр-т E. Муньє 53, Брюссель, B1200, Бельгія
  3. Клініка університета Санкт-Люк
    пр.-т Гіппократ 10, B1200 Брюссель, Бельгія

Abstract

Незважаючи на інтенсивні дослідження, механізми активації цитокінових рецепторів наразі є не зовсім зрозумілими. Історично було запропоновано дві моделі: у ранніх роботах припускали механізм ліганд-індукованої димеризації рецепторів, що призводить до активації більш пізніх сигнальних шляхів, у той час як за відсутності лігандів рецептори перебувають у мономерому неактивованому стані; подальшими дослідженнями виявлено докази існування багатьох рецепторів у формі неактивованих сформованих димерів, які при зв’язуванні ліганда зазнають конформаційних змін та/або мономери яких починають ротаційно переміщуватися відносно один одного. Даний огляд сфокусовано на проблемі димеризації окремих гомодимерних рецепторів цитокінів, які причетні до регуляції кровотворення.
Keywords: рецептори цитокінів, димеризація, гематопоез
Повний текст: (PDF, англійською)

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