Biopolym. Cell. 2014; 30(2):83-89.
http://dx.doi.org/10.7124/bc.000885
Огляди
Упакований геном як основа функціональної компартменталізації ядра евкаріотичної клітини
1, 2Юдінкова Є. С., 1, 2Гаврилов А. А., 1, 2, 3Разін С. В.
  1. Інститут біології гена РАН
    вул. Вавілова 34/5, Москва, Російська Федерація, 119334
  2. LIA 1066 Об'єднана французько-російська лабораторія з дослідження раку
    Вільжюіф, Франція-Москва, Російська Федерація
  3. Кафедра молекулярної біології, біологічний факультет, Московський державний університет імені М. В. Ломоносова
    Ленінські гори, Російська Федерація, 119991

Abstract

У низці недавніх робіт продемонстровано тісний взаємозв’язок між просторовою організацією евкаріотичного геному і його функціонуванням. Більш того, стає очевидним, що упакована ДНК сама по собі є важливим, якщо не ключовим, фактором, котрий підтримує внутрішню організацію ядра. В огляді ми обговорюємо існуючий стан досліджень у галузі хроматину, акцентуючи увагу на питаннях, пов’язаних з хромосомними територіями, фолдингом і динамікою хроматину, а також хроматиновим доменам, транскрипційним і реплікаційним фабрикам. На основі цього ми показуємо, що інтерфазні хромосоми визначають збирання різних ядерних компартментів і створюють підгрунтя для просторової компартменталізації клітинного ядра.
Keywords: фолдинг хромосом, ядерні компартменти, просторова організація геному
Повний текст: (PDF, англійською)

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