Biopolym. Cell. 2013; 29(5):357-366.
http://dx.doi.org/10.7124/bc.00082A
Огляди
Області застосування рослинних лектинів
1Мельникова Н. М., 1Михалків Л. М., 1Маменко П. М., 1Коць С. Я.
  1. Інститут фізіології рослин і генетики НАН України
    вул. Васильківська, 31/17, Київ, Україна, 03022

Abstract

Лектини, зокрема, лектини рослин є білками неімунного походження, здатні зв’язувати вуглеводи з високою специфічністю. Завдяки своїм властивостям фітолектини викликають значний інтерес щодо їхнього практичного застосування. Показано, що вони відіграють важливу роль при розробці стратегії лікування захворювань, включаючи рак і ВІЛ, а також у дослідженні глікому клітини. Рослинні лектини з фунгіцидною та інсектицидною активністю використовують у трансгенних технологіях для підвищення стійкості рослин до фітопатогенів і комах. Інтродукція генів лектинових кіназ у геном рослини може бути перспективним напрямом захисту останньої від дії стресових чинників навколишнього середовища і регулювання її росту. Конструювання фітолектинів дозволяє отримувати молекули з певною вуглеводною специфічністю, що розширює сферу застосування зазначених білків. Проводять також дослідження для створення фармацевтичних препаратів, які містять лектини рослин, та систем спрямованої доставки ліків на основі лектинів. Через здатність фітолектинів взаємодіяти з різними речовинами вони можуть мати ширше використання в майбутньому. Огляд охоплює сучасні дані та перспективні напрямки практичного застосування рослинних лектинів.
Keywords: лектини рослин, біотехнологія, дослідження глікому, біомедичні дослідження, сільське господарство
Повний текст: (PDF, англійською)

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