Biopolym. Cell. 2013; 29(4):266-276.
Огляди
2'-5'-олігоаденілати як «інструмент» уродженого імунітету
1Ткачук З. Ю.
- Інститут молекулярної біології і генетики НАН України
Вул. Академіка Заболотного, 150, Київ, Україна, 03680
Abstract
Відомо, що «кори» 2'-5'-олігоаденілатів та їхніх аналоги володіють значно ширшою біологічною активністю, ніж це можна передбачити в рамках традиційної «інтерферонової» гіпотези. Вони проявляють імуномодулюючу дію і є ефективними імуносупресорами при трансплантації органів і тканин. Олігоаденілатам притаманна противірусна активністю стосовно широкого спектра як ДНК-, так і РНК-вмісних вірусів. Ці препарати регулюють апоптоз і проліферацію клітин та володіють протипухлинною активністю. Така полівалентна активність олігоаденілатів базується на можливості зв’язуватися з сигнальними білками, що призводить до зміни їхньої конформації та модуляції активності. Вони також можутьпорушувати вторинну структуру вірусних ДНК і РНК і роблять їх доступними для розщеплення клітинними ферментами. Запропоновано гіпотезу, яка пояснює механізм противірусної дії 2'-5'-олігоаденілатів, а також наведено експериментальні дані на її користь.
Keywords: 2'-5'-олігоаденілати, 2'-5'-олігоаденілатсинтетаза, -інтерферон, протеїнкінази, Са2+-зв’язувальні білки, РНК-, ДНК-віруси
Повний текст: (PDF, англійською)
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