Biopolym. Cell. 2013; 29(1):11-20.
Огляди
Різноманіття функцій та ефектів кіспептину
1Матвієнко М. Г., 1Пустовалов А. С., 1Дзержинський М. Е.
- Навчально-науковий центр «Інститут біології»
Київського національного університету імені Тараса Шевченка
вул. Володимирська, 64/13, Київ, Україна, 01601
Abstract
Представлено короткий огляд літературних даних з дослідження властивостей та ефективності застосування кіспептину, зокрема, для регуляції ендокринних функцій організму. Проаналізовано численні результати експериментів з використанням кіспептину в молекулярній біології, репродуктивної медицині, ендокринології, а також при розробці вакцин проти злоякісних утворень. Згаданий пептид ініціює каскад змін, які призводять до пубертату. За наявними даними, кіспептин змінює активність залоз, які продукують статеві гормони, внаслідок чого він може знайти застосування у лікуванні захворювань, пов’язаних з порушенням пубертату, зокрема, аменореї у дівчат-підлітків. Дія цього пептиду обумовлена активацією клітин гіпоталамуса, що виділяють гонадоліберин, який регулює рівень гонадотропних гормонів. У той же час кіспептин активує репродуктивну систему, не порушуючи при цьому захисних механізмів організму. Видається перспективним більш поглиблене вивчення ефекту кіспептину на всі ланки гіпоталамо-гіпофізарно-гонадальної осі, а також дослідження нейроно-гліальних взаємодій у центральній нервовій системі під впливом даного пептиду.
Keywords: кіспептин, гонадотропний рилізинг-гормон, гіпоталамо-гіпофізарно-гонадальна вісь
Повний текст: (PDF, англійською)
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