Biopolym. Cell. 2012; 28(5):338-351.
http://dx.doi.org/10.7124/bc.000061
Огляди
Алельний поліморфізм рецептора глюкокортикоїдних гормонів NR3C1 (GR): від молекулярної біології до клініки
1Орловський М. О.
  1. Інститут фізиології ім. О. О. Богомольця НАН України
    вул. Академіка Богомольця, 4, Київ, Україна, 01024

Abstract

Поліморфізм генів, які беруть участь у реалізації стресорної відповіді, є одним із ключових факторів, що визначають розбіжності в стрес-реактивності і резистентності в людській популяції. Серед генів – регуляторів стресу у першу чергу варто відзначити гени рецепторів глюкокортикоїдів. В огляді надано детальну характеристику молекулярної біології даних генів, на підставі чого зроблено аналіз можливого зв’язку найрозповсюдженіших варіантів SNP з альтерацією стресорних реакцій та розвитком клінічної патології.
Keywords: глюкокортикоїдні рецептори, алельний поліморфізм, SNP, NR3C1, GR, захворювання адаптації
Повний текст: (PDF, російською) (PDF, англійською)

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